CONTROLLED ASYMMETRICAL DIFFERENTIATION OF MOUSE EMBRYOID BODIES IN MICROWELLS WITH DESIGNED HETEROGENEOUS BIOCHEMICAL FEATURES

被引：1

作者：

Qi, Hao ^{[1
]}

Xu, Feng ^{[2
]}

机构：

[1] Xi An Jiao Tong Univ, Sch Life Sci & Technol, MOE Key Lab Biomed Informat Engn, Xian 710049, Peoples R China

[2] Xi An Jiao Tong Univ, Bioinspired Engn & Biomech Ctr, Xian 710049, Peoples R China

来源：

JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY | 2013年 / 13卷 / 05期

关键词：

Stem cell; embryoid bodies (EBs); hydrogel; differentiation; INDUCED DNA-DAMAGE; STEM-CELLS; APOPTOSIS; REPAIR; SIZE; FATE;

D O I：

10.1142/S0219519413400034

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

We report a novel engineered microwells to spatially control differentiation of mouse embryoid bodies. With integrating multiple functionally distinct biomaterials by soft-photolithography technology, this method enables simple and reliable manufacture of biochemically heterogeneous microwells that are capable of regulating differentiation of stem cell in a spatial-specific manner. This simple technology offers a new dimension of spatial control over embryoid bodies development and has great potential in tissue engineering and biomedical applications.

引用

页数：10

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