Receptor for advanced glycation end products modulates oxidative stress and mitochondrial function in the soleus muscle of mice fed a high-fat diet

被引:11
作者
Velayoudom-Cephise, Fritz Line [1 ,2 ]
Cano-Sanchez, Mariola [2 ,3 ]
Bercion, Sylvie [2 ,4 ]
Tessier, Frederic [5 ]
Yu, Yichi [5 ,6 ]
Boulanger, Eric [5 ]
Neviere, Remi [2 ,3 ]
机构
[1] Univ Hosp CHU Guadeloupe, F-97110 Pointe A Pitre, Guadeloupe, France
[2] Univ French West Indies, EA7525, F-97159 Fort De France, Martinique, France
[3] Univ Hosp CHU Martinique, F-97200 Fort De France, Martinique, France
[4] Fac Nat Sci, Dept Chem, F-97110 Pointe A Pitre, Guadeloupe, France
[5] Lille Univ, LIRIC Team Glycat Inflammat Aging, INSERM, U995, F-59000 Lille, France
[6] Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China
关键词
advanced glycation end products; exercise; skeletal muscle; mitochondria; mice; high-fat diet; RAGE; ACCUMULATION; DYSFUNCTION; INSULIN; ANTIOXIDANT; ENDPRODUCTS; INVOLVEMENT;
D O I
10.1139/apnm-2019-0936
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Accumulation of advanced glycation end products (AGEs) and activation of the receptor for AGEs (RAGE) are implicated in the progression of pathologies associated with aging, chronic inflammation, diabetes, and cellular stress. RAGE activation is also implicated in cardiovascular complications of type 2 diabetes, such as nephropathy, retinopathy, accelerated vascular diseases, and cardiomyopathy. Studies investigating the effects of AGE/RAGE axis activation on skeletal muscle oxidative stress and metabolism are more limited. We tested whether a high-fat diet (HFD) would alter circulating AGE concentration, skeletal muscle AGE accumulation, and oxidative stress in wild-type and RAGE-deficient mice. The physiological significance of AGE/RAGE axis activation in HFD-fed mice was evaluated in terms of exercise tolerance and mitochondrial respiratory chain complex activity. HFD elicited adiposity, abnormal fat distribution, and oral glucose intolerance. HFD also induced accumulation of N3-carboxymethyl-L-lysine, increased protein carbonyl levels, and impaired respiratory chain complex activity in soleus muscle. Ablation of RAGE had no effects on weight gain and oral glucose tolerance in HFD-fed mice. Peak aerobic capacity and mitochondrial cytochrome-c oxidase activity were restored in HFD-fed RAGE(-/-) mice. We concluded that RAGE signaling plays an important role in skeletal muscle homeostasis of mice under metabolic stress. Novelty HFD in mice induces accumulation of AGEs, oxidative stress, and mitochondrial dysfunction in the soleus muscle. RAGE, the multi-ligand receptor for AGEs, modulates oxidative stress and mitochondrial electron transport chain function in the soleus muscle of HFD-fed mice.
引用
收藏
页码:1107 / 1117
页数:11
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