Association of dietary and supplemental iron and colorectal cancer in a population-based study

被引:15
作者
Ashmore, Joseph H. [1 ]
Lesko, Samuel M. [2 ]
Miller, Paige E. [6 ]
Cross, Amanda J. [7 ]
Muscat, Joshua E. [3 ]
Zhu, Junjia [3 ]
Liao, Jason [3 ]
Harper, Gregory [5 ]
Lazarus, Philip [3 ,4 ]
Hartman, Terryl J. [1 ]
机构
[1] Penn State Univ, Dept Nutr Sci, University Pk, PA 16802 USA
[2] Northeast Reg Canc Inst, Scranton, PA USA
[3] Penn State Coll Med, Dept Publ Hlth Sci, Hershey, PA USA
[4] Penn State Coll Med, Dept Pharmacol, Hershey, PA USA
[5] Lehigh Valley Hosp, Dept Med & Pharmacol, Allentown, PA USA
[6] Exponent Inc, Dept Hlth Sci, Chicago, IL USA
[7] NCI, Dept Hlth & Human Serv, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
关键词
colorectal cancer; heme; iron; supplements; HEME IRON; COLON-CANCER; RED MEAT; ALCOHOL-CONSUMPTION; RISK; WOMEN; ZINC; VALIDATION; OVERLOAD; DISEASES;
D O I
10.1097/CEJ.0b013e32836056f8
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We evaluated the role of dietary iron, heme iron, and supplemental iron on colorectal cancer (CRC) risk in a population-based case-control study in Pennsylvania, including 1005 incident cases and 1062 controls. Diet was assessed through a modified food frequency questionnaire that included supplement use and a meat-specific module. Cases reported intakes for the year before diagnosis, whereas controls reported intakes for the year before interview. Heme iron intake was calculated using a new heme database developed by the US National Cancer Institute. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression. After multivariate adjustment, there were no significant associations between heme iron or total iron intake and CRC incidence. Dietary iron intake was inversely associated with CRC among women (OR Q(5) vs. Q(1)=0.45; 95% CI=0.22-0.92), but not among men. Supplemental iron intake of more than 18 mg/day versus none was positively associated with CRC incidence (OR=2.31; 95% CI=1.48-3.59; P-trend<0.001), an effect that was observed in both men (OR=2.56; 95% CI=1.30-5.05) and women (OR=2.46; 95% CI=1.34-4.52). These findings suggest that consumption of more than 18 mg/day of supplemental iron may increase risk for CRC. (C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
引用
收藏
页码:506 / 511
页数:6
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