Effect of gonadotropin-releasing hormone agonist and antagonist on proliferation and apoptosis of human luteinized granulosa cells

被引：22

作者：

Vitale, AM ^{[1
]}

Abramovich, D ^{[1
]}

Peluffo, MC ^{[1
]}

Meresman, G ^{[1
]}

Tesone, M ^{[1
]}

机构：

[1] Fac Ciencias Exactas & Nat Buenos Aires, CONICET, Inst Biol & Med Expt, RA-1428 Buenos Aires, DF, Argentina

来源：

FERTILITY AND STERILITY | 2006年 / 85卷 / 04期

关键词：

D O I：

10.1016/j.fertnstert.2005.09.061

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The GnRH agonist leuprolide acetate (LA) inhibited DNA synthesis in epidermal growth factor-stimulated human granulosa luteinized cell cultures. This effect was blocked by the prior addition of a GnRH antagonist antide (ANT), and this compound per se was able to produce a stimulatory effect of DNA synthesis on basal conditions. Leuprolide acetate produced an increase in the percentage of apoptotic cells, and when these two factors were co-incubated.

引用

页码：1064 / 1067

页数：4

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