Repeating an abnormal prostate-specific antigen (PSA) level: how relevant is a decrease in PSA?

被引：9

作者：

Connolly, D. ^{[1
,2
]}

Black, A. ^{[2
]}

Murray, L. J. ^{[2
]}

Nambirajan, T. ^{[1
]}

Keane, P. F. ^{[1
]}

Gavin, A. ^{[3
]}

机构：

[1] Belfast City Hosp, Dept Urol, Belfast BT9 7AB, Antrim, North Ireland

[2] Queens Univ Belfast, Canc Epidemiol & Prevent Res Grp, Belfast, Antrim, North Ireland

[3] Queens Univ Belfast, No Ireland Canc Registry, Belfast, Antrim, North Ireland

来源：

PROSTATE CANCER AND PROSTATIC DISEASES | 2009年 / 12卷 / 01期

关键词：

decrease; pattern; PSA; variability; BIOLOGICAL VARIATION; CANCER DETECTION; MEN; VOLUNTEERS;

D O I：

10.1038/pcan.2008.37

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To examine the practice of repeating an abnormal prostate-specific antigen (PSA) level before proceeding to prostate biopsy, we assessed the pattern of PSA change following an initially raised (>= 4.0 ng ml(-1)) PSA, and the relationship of this to prostate cancer diagnosis. In 7052 men, 71.2% with initially raised PSA had a reduction in PSA, with values <4.0 ng ml(-1) in 37.8%. A total of 43.0% of men with prostate cancer showed a PSA decrease below their baseline level. Short-term decreases in PSA may occur in men with prostate cancer, including high-grade cancer, and so should not influence the decision to proceed to prostate biopsy.

引用

页码：47 / 51

页数：5

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