Copper-catalyzed three-component cyclization of amidines, styrenes, and fluoroalkyl halides for the synthesis of modular fluoroalkylated pyrimidines

被引：58

作者：

Chu, Xue-Qiang ^{[1
]}

Cheng, Bu-Qing ^{[1
]}

Zhang, Yao-Wei ^{[1
]}

Ge, Danhua ^{[1
]}

Shen, Zhi-Liang ^{[1
]}

Loh, Teck-Peng ^{[1
,2
]}

机构：

[1] Nanjing Tech Univ, Inst Adv Synth, Sch Chem & Mol Engn, Jiangsu Natl Synerget Innovat Ctr Adv Mat, Nanjing 211816, Jiangsu, Peoples R China

[2] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 21期

关键词：

ALKENES; FUNCTIONALIZATION; HYDROPEROXIDES; DERIVATIVES; FLUORINE; ALCOHOLS; IODIDES; ALKYNES;

D O I：

10.1039/c7cc09571f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient copper-catalyzed three-component cyclization for the construction of highly functionalized pyrimidine derivatives from readily available amidines, styrenes and fluoroalkyl halides is developed. This protocol distinguishes itself by the formation of three new C-C/C-N bonds and a new six-membered ring through a radical addition/oxidation/cyclization sequence in a one-pot manner.

引用

页码：2615 / 2618

页数：4

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