Epigenetic mechanisms in migraine: a promising avenue?

被引：89

作者：

Eising, Else ^{[1
]}

Datson, Nicole A. ^{[1
]}

van den Maagdenberg, Arn M. J. M. ^{[1
,2
]}

Ferrari, Michel D. ^{[2
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Human Genet, NL-2333 ZC Leiden, Netherlands

[2] Leiden Univ, Med Ctr, Dept Neurol, NL-2333 ZA Leiden, Netherlands

来源：

BMC MEDICINE | 2013年 / 11卷

关键词：

DNA methylation; epigenetics; GWAS; histone modifications; inflammation; migraine; stress; valproate; GENOME-WIDE ASSOCIATION; FAMILIAL HEMIPLEGIC MIGRAINE; GRANULE CELL DISPERSION; SPREADING DEPRESSION; CHROMATIN REGULATION; SUSCEPTIBILITY LOCI; SEX-DIFFERENCES; MOUSE MODEL; ESTROGEN; METHYLATION;

D O I：

10.1186/1741-7015-11-26

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Migraine is a disabling common brain disorder typically characterized by attacks of severe headache and associated with autonomic and neurological symptoms. Its etiology is far from resolved. This review will focus on evidence that epigenetic mechanisms play an important role in disease etiology. Epigenetics comprise both DNA methylation and post-translational modifications of the tails of histone proteins, affecting chromatin structure and gene expression. Besides playing a role in establishing cellular and developmental stage-specific regulation of gene expression, epigenetic processes are also important for programming lasting cellular responses to environmental signals. Epigenetic mechanisms may explain how non-genetic endogenous and exogenous factors such as female sex hormones, stress hormones and inflammation trigger may modulate attack frequency. Developing drugs that specifically target epigenetic mechanisms may open up exciting new avenues for the prophylactic treatment of migraine.

引用

页数：6

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