Season of birth as a risk factor for multiple sclerosis in Brazil

被引：9

作者：

Becker, Jefferson ^{[1
]}

Callegaro, Dagoberto ^{[2
]}

Lana-Peixoto, Marco Aurelio ^{[3
]}

Ferreira, Maria Lucia B. ^{[4
]}

Melo, Ailton ^{[5
]}

da Gama, Paulo Diniz ^{[6
]}

Souza, Doralina G. B. ^{[7
,8
]}

Teixeira, Carlos A. C. ^{[9
]}

Kaimen-Maciel, Damacio Ramon ^{[10
]}

Goncalves, Marcus Vinicius ^{[11
]}

Matta, Andre P. C. ^{[12
]}

Abraham, Ronaldo ^{[13
]}

Furtado, Luis Edmundo T. A. ^{[14
]}

Lino, Angelina ^{[2
]}

Hauck, Laura ^{[1
]}

Barreira, Amilton Antunes ^{[7
]}

Gomes, Irenio ^{[1
]}

机构：

[1] Hosp Sao Lucas PUCRS, BR-90610000 Porto Alegre, RS, Brazil

[2] Hosp Clin USP, Sao Paulo, Brazil

[3] CIEM Univ Fed Minas Gerais, Belo Horizonte, MG, Brazil

[4] Hosp Restauracao, Recife, PE, Brazil

[5] Hosp Univ Prof Edgard Santos UFBA, Salvador, BA, Brazil

[6] Conjunto Hosp Sorocaba PUCSP, Sorocaba, SP, Brazil

[7] Hosp Clin FMRP USP, Ribeirao Preto, SP, Brazil

[8] Univ Estadual Paulista, UNESP, Botucatu, SP, Brazil

[9] Univ Fed Ceara, Fortaleza, CE, Brazil

[10] Univ Estadual Londrina, Londrina, PR, Brazil

[11] Clin Neurol Joinville, Joinville, SC, Brazil

[12] Univ Fed Fluminense, Niteroi, RJ, Brazil

[13] Univ Taubate, Dept Med, Taubate, SP, Brazil

[14] Univ Fed Ceara, Sobral, CE, Brazil

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2013年 / 329卷 / 1-2期

关键词：

Season of birth; Month of birth; Risk factor; Multiple sclerosis; Vitamin D; MS epidemiology; VITAMIN-D SUPPLEMENTATION; NEW-ZEALAND; AUSTRALIA; POPULATION; DISEASES; DISORDERS; PREGNANCY;

D O I：

10.1016/j.jns.2013.03.001

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Risk factors for development of multiple sclerosis (MS) are still a matter of debate. Latitude gradient, vitamin D deficiency and season of birth are among the most investigated environmental factors associated with the disease. Several international studies suggest that birth in spring is a substantial risk factor for MS. We investigated the season of birth as a potential risk for MS in different geographical regions of Brazil. We conducted a cross-sectional retrospective study with 2257 clinically definite MS patients enrolled in 13 Brazilian MS clinics in the south, southeast, and northeast regions of Brazil. Demographic and clinical data relating to date of birth and clinical features of the disease were collected and analysed, and subsequently compared with birth date among the general Brazilian population. The distribution of date of birth of MS patients showed an increase in spring and a decrease in autumn, with no difference being observed in the other seasons. In conclusion, season of birth is a probable risk factor for MS in most parts of Brazil. These findings may be related to the role that vitamin D plays in MS pathogenesis. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：6 / 10

页数：5

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