Intraventricular interferon-alpha stops seizures in Rasmussen's encephalitis: A case report

被引：26

作者：

Dabbagh, O ^{[1
]}

Gascon, G ^{[1
]}

Crowell, J ^{[1
]}

Bamoggadam, F ^{[1
]}

机构：

[1] BROWN UNIV, SCH MED, DEPT PEDIAT, PROVIDENCE, RI 02912 USA

来源：

EPILEPSIA | 1997年 / 38卷 / 09期

关键词：

intraventricular interferon-alpha; Rasmussen's encephalitis; epilepsia partialis continua;

D O I：

10.1111/j.1528-1157.1997.tb01491.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A 3.5-year-old girl had epilepsia partialis continua of the right side. Clinical and laboratory findings were consistent with Rasmussen's encephalitis. Treatment with high-dose methylprednisolone led to temporary control of seizures, but for 2 years, the seizures remained refractory to phenobarbital, phenytoin, lorazepam, carbamazepine, valproic acid, vigabatrin, gabapentin, and lamotrigine. A 6-week course, and later a 6-month course, of intraventricular interferon-alpha almost totally suppressed the seizures. Although moderately hemiparetic, the child has reasonable neurologic function with mild speech delay. She is receiving her third course of treatment, and seizures remain completely controlled.

引用

页码：1045 / 1049

页数：5

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