Prediction of intracranial atherosclerotic acute large vessel occlusion by severe hypoperfusion volume growth rate

Background and purpose: We aimed to investigate whether the time elapsed from stroke onset to imaging (OTI) combined with the parameters generated by auto-mated computed tomography perfusion (CTP) could predict large vessel occlusion (LVO) patients with underlying intracranial atherosclerotic disease (ICAD) before endovascular treatment (EVT). Methods: We performed a prospective cohort of LVO patients with automated CTP before EVT from two comprehensive stroke cen-ters. Severe hypoperfusion volume growth rate was defined as the Time-to -Maxi-mum (Tmax) > 10s divided by OTI. We performed receiver operating characteristic analyses to assess the ICAD prediction performance of all the automated CTP parameters, Delong test to compare the area under the curve (AUC) of severe hypo -perfusion volume growth rate with the AUC of the other parameters, and logistic regression analysis to find the independent predictors of LVO with underlying ICAD. Results: Of the 204 enrolled LVO patients, 95 ICAD patients and 109 non-ICAD patients were identified. The AUC of severe hypoperfusion volume growth rate was 0.86 (95% confidence interval [CI] 0.81 -0.91, P < 0.001), the cut-off value with the highest Youden Index was < 11.2 mL/h (sensitivity, 78.95%; specificity, 77.06%; accuracy 77.94%), which was larger than the other parameters except for hypoperfusion intensity ratio (HIR) (All P for Delong test < 0.05). Atrial fibrillation (odds ratio [OR]: 0.09, 95%CI: 0.03 -0.26, P < 0.001), admission ASPECTS (1-point increased OR: 1.25, 95%CI: 1.03 -1.53, P = 0.024), and severe hypoperfusion vol-ume growth rate (1 mL/h increased OR: 0.94, 95%CI: 0.90 -0.98, P = 0.003) were associated with underlying ICAD independently. Conclusions: Severe hypoperfu-sion volume growth rate showed the best performance for LVO with underlying ICAD prediction. Future larger studies for external validation are needed.