Study of arabinogalactan supramolecular structure using synchrotron radiation SAXS and terahertz laser ablation methods

被引：4

作者：

Mikhailenko, M. A. ^{[1
]}

Sharafutdinov, M. R. ^{[1
,2
]}

Kozlov, A. S. ^{[3
]}

Kuznetsova, S. A. ^{[4
]}

Shakhtshneider, T. P. ^{[1
,5
]}

Zolotarev, K., V ^{[2
]}

机构：

[1] Inst Solid State Chem & Mechanochem SB RAS, Kutateladze Str 18, Novosibirsk 630128, Russia

[2] Budker Inst Nucl Phys SB RAS, Lavrentiev Ave 11, Novosibirsk 630090, Russia

[3] VV Voevodsky Inst Chem Kinet & Combust SB RAS, Inst Skaya Str 3, Novosibirsk 630090, Russia

[4] Inst Chem & Chem Technol SB RAS, Academgorodok 50-24, Krasnoyarsk 630036, Russia

[5] Novosibirsk State Univ, Pirogova Str 2, Novosibirsk 630090, Russia

来源：

Proceedings of the International Conference Synchrotron and Free Electron Laser Radiation: Generation and Application (SFR-2016) | 2016年 / 84卷

基金：

俄罗斯科学基金会;

关键词：

Arabinogalactan; synchrotron small-angle X-ray scattering; THz laser ablation; polymer associates;

D O I：

10.1016/j.phpro.2016.11.065

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Arabinogalactan, a water-soluble natural polysaccharide, has potent innate immuno-modulatory and anti-cancer activity and can serve as a carrier material in targeted drug delivery. The molecular weight and supramolecular structure of the polymer are very important for its pharmacological and technological applications. In this work, we used synchrotron small-angle X-ray scattering as an instrument to study the supramolecular structure of arabinogalactan in aqueous solutions. The formation of polymer associates was confirmed also by means of the terahertz laser ablation and atomic force microscopy studies. SAXS experiments were made at accelerators complex VEPP-3/VEPP-4. (C) 2016 The Authors. Published by Elsevier B.V.

引用

页码：382 / 385

页数：4

共 9 条

[1] One-coordinate X-ray detector OD-3M [J].

Aulchenko, V. M. ;

Evdokov, O. V. ;

Kutovenko, V. D. ;

Pirogov, B. Ya. ;

Sharafutdinov, M. R. ;

Titov, V. M. ;

Tolochko, B. P. ;

Vasiljev, A. V. ;

Zhogin, I. A. ;

Zhulanov, V. V. .

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 2009, 603 (1-2) :76-79

[2] Polysaccharide arabinogalactan from larch Larix sibirica as carrier for molecules of salicylic and acetylsalicylic acid: preparation, physicochemical and pharmacological study [J].

Chistyachenko, Yulia S. ;

Dushkin, Alexandr V. ;

Polyakov, Nikolay E. ;

Khvostov, Mikhail V. ;

Tolstikova, Tatyana G. ;

Tolstikov, Genrikh A. ;

Lyakhov, Nikolay Z. .

DRUG DELIVERY, 2015, 22 (03) :400-407

[3]

Dion C., 2016, NUTR METAB, V13, P86

[4] Structure function relationships of immunostimulatory polysaccharides: A review [J].

Ferreira, Sonia S. ;

Passos, Claudia P. ;

Madureira, Pedro ;

Vilanova, Manuel ;

Coimbra, Manuel A. .

CARBOHYDRATE POLYMERS, 2015, 132 :378-396

[5]

Goryachkovskaya T. N., 2015, RUSSIAN J GENETICS A, V5, P394

[6]

Kuznetsova S. A., 2006, Russian Federation patent, Patent No. 2273646

[7] Supramolecular architecture of betulin diacetate complexes with arabinogalactan from Larix sibirica [J].

Mikhailenko, Mikhail A. ;

Shakhtshneider, Tatyana P. ;

Eltsov, Ilia V. ;

Kozlov, Alexander S. ;

Kuznetsova, Svetlana A. ;

Karacharov, Anton A. ;

Boldyrev, Vladimir V. .

CARBOHYDRATE POLYMERS, 2016, 138 :1-7

[8] New composites of betulin esters with arabinogalactan as highly potent anti-cancer agents [J].

Shakhtshneider, T. P. ;

Kuznetsova, S. A. ;

Zamay, A. S. ;

Zamay, T. N. ;

Spivak, E. A. ;

Mikhailenko, M. A. ;

Malyar, Yu. N. ;

Kuznetsov, B. N. ;

Chesnokov, N. V. ;

Boldyrev, V. V. .

NATURAL PRODUCT RESEARCH, 2016, 30 (12) :1382-1387

[9] Structurally characterized arabinogalactan from Anoectochilus formosanus as an immuno-modulator against CT26 colon cancer in BALB/c mice [J].

Yang, Li-Chan ;

Hsieh, Chang-Chi ;

Lu, Ting-Jang ;

Lin, Wen-Chuan .

PHYTOMEDICINE, 2014, 21 (05) :647-655

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