Control of Intra-Thymic αβ T Cell Selection and Maturation by H3K27 Methylation and Demethylation

被引：4

作者：

Bosselut, Remy ^{[1
]}

机构：

[1] NCI, Lab Immune Cell Biol, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

来源：

FRONTIERS IN IMMUNOLOGY | 2019年 / 10卷

基金：

美国国家卫生研究院;

关键词：

thymus; T cell development; histone methylation; histone demethyalse; polycomb; H3K27; methylation; LYSINE; 27; DEMETHYLASES; II NKT CELLS; POSITIVE SELECTION; LINEAGE FATE; STEM-CELLS; TRANSCRIPTIONAL REGULATION; CHROMATIN MODIFICATIONS; THYMOCYTE DEVELOPMENT; REPRESSIVE CHROMATIN; HISTONE DEMETHYLASES;

D O I：

10.3389/fimmu.2019.00688

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In addition to transcription factor binding, the dynamics of DNA modifications (methylation) and chromatin structure are essential contributors to the control of transcription in eukaryotes. Research in the past few years has emphasized the importance of histone H3 methylation at lysine 27 for lineage specific gene repression, demonstrated that deposition of this mark at specific genes is subject to differentiation-induced changes during development, and identified enzymatic activities, methyl transferases and demethylases, that control these changes. The present review discusses the importance of these mechanisms during intrathymic alpha beta T cell selection and late differentiation.

引用

页数：11

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