Allosteric Modulation of lonotropic Glutamate Receptors: An Outlook on New Therapeutic Approaches To Treat Central Nervous System Disorders

被引：38

作者：

Brogi, Simone ^{[1
,2
]}

Campiani, Giuseppe ^{[1
]}

Brindisi, Margherita ^{[1
]}

Butini, Stefania ^{[1
]}

机构：

[1] Univ Siena, Dept Biotechnol Chem & Pharm, DoE Dept Excellence 2018 2022, Via Aldo Moro 2, I-53100 Siena, Italy

[2] Univ Napoli Federico II, Dept Pharm, DoE Dept Excellence 2018 2022, Via D Montesano 49, I-80131 Naples, Italy

来源：

ACS MEDICINAL CHEMISTRY LETTERS | 2019年 / 10卷 / 03期

关键词：

Allosteric modulation; ionotropic glutamate receptors (iGluRs); positive allosteric modulator (PAM); negative allosteric modulator (NAM); CNS-related disorders; NMDA RECEPTOR; AMPA RECEPTORS; ACID AMPA; DISCOVERY; ANTAGONIST; POTENTIATOR; DISTINCT; BINDING; 1,1-DIOXIDES; MECHANISMS;

D O I：

10.1021/acsmedchemlett.8b00450

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The allosteric targeting of ionotropic glutamate receptors (iGluRs) is a valuable approach for treating various central nervous system (CNS) disorders. In this frame, this Innovations provides a summary of the state-of-the art in the development of allosteric modulators for iGluRs and offers an outlook regarding innovative strategies for treating neurological diseases.

引用

页码：228 / 236

页数：17

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