Type 1 Adenylyl Cyclase Is Essential for Maintenance of Remote Contextual Fear Memory

被引：34

作者：

Shan, Qiang ^{[1
]}

Chan, Guy C. -K. ^{[1
]}

Storm, Daniel R. ^{[1
]}

机构：

[1] Univ Washington, Dept Pharmacol, Seattle, WA 98195 USA

来源：

JOURNAL OF NEUROSCIENCE | 2008年 / 28卷 / 48期

基金：

美国国家卫生研究院;

关键词：

calcium-sensitive adenylyl cyclase; anterior cingulate cortex; remote memory; contextual fear conditioning; memory maintenance; memory extinction;

D O I：

10.1523/JNEUROSCI.2413-08.2008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Although molecular mechanisms for hippocampus-dependent memory have been extensively studied, much less is known about signaling events important for remote memory. Here we report that mice lacking type 1 adenylyl cyclase (AC1) are able to establish and retrieve remote contextual memory but unable to sustain it as long as wild-type mice. Interestingly, mice overexpressing AC1 show superior remote contextual memory even though they exhibit normal hippocampus-dependent contextual memory. These data illustrate that calcium coupling to cAMP contributes to the stability of remote memory and identifies AC1 as a potential drug target site to improve long-term remote memory.

引用

页码：12864 / 12867

页数：4