Sphingosine 1-phosphate receptors: from biology to physiopathology

被引：22

作者：

Cuvillier, Olivier ^{[1
]}

机构：

[1] CNRS, UMR 5089, Inst Pharmacol & Biol Struct, F-31077 Toulouse 4, France

来源：

M S-MEDECINE SCIENCES | 2012年 / 28卷 / 11期

关键词：

EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; PROTEIN-COUPLED RECEPTOR; IN-VIVO; LYSOPHOSPHOLIPID RECEPTOR; DEFICIENT MICE; NULL MICE; SPHINGOSINE-1-PHOSPHATE; ACTIVATION; SURVIVAL; FTY720;

D O I：

10.1051/medsci/20122811013

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Sphingosine 1-phosphate receptors: from biology to physiopathology Sphingosine 1-phosphate (S1P) mediates critical physiological responses by its binding to G protein-coupled receptor (GPCR) subtypes, known as S1P receptors. Five distinct mammalian S1P receptors, designated S1P1-5 have been identified, each with a different cellular pattern of expression which influences the responses to S1P. In this review, we briefly outline our understanding of the modes of action and the roles of S1P receptors in the regulation of physiological and pathological functions in the cardiovascular, immune and central nervous sytem.

引用

页码：951 / 957

页数：7

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