Development of Customizable Implementation Guides to Support Clinical Adoption of Pharmacogenomics: Experiences of the Implementing GeNomics In pracTicE (IGNITE) Network

被引：13

作者：

Duong, Benjamin Q. ^{[1
]}

Arwood, Meghan J. ^{[2
,3
]}

Hicks, J. Kevin ^{[4
]}

Beitelshees, Amber L. ^{[5
]}

Franchi, Francesco ^{[6
]}

Houder, John T. ^{[2
,3
]}

Limdi, Nita A. ^{[7
]}

Cook, Kelsey J. ^{[8
,9
]}

Obeng, Aniwaa Owusu ^{[10
]}

Petry, Natasha ^{[11
]}

Tuteja, Sony ^{[12
]}

Elsey, Amanda R. ^{[2
,3
]}

Cavallari, Larisa H. ^{[2
,3
]}

Wiisanen, Kristin ^{[2
,3
]}

机构：

[1] Nemours Alfred I DuPont Hosp Children, Dept Precis Med, Wilmington, DE USA

[2] Univ Florida, Coll Pharm, Dept Pharmacotherapy & Translat Res, POB 100486, Gainesville, FL 32610 USA

[3] Univ Florida, Coll Pharm, Ctr Pharmacogen & Precis Med, POB 100486, Gainesville, FL 32610 USA

[4] H Lee Moffitt Canc Ctr & Res Inst, Dept Individualized Canc Management, Tampa, FL USA

[5] Univ Maryland, Sch Med, Dept Med, Baltimore, MD 21201 USA

[6] Univ Florida, Coll Med, Dept Cardiol, Jacksonville, FL USA

[7] Univ Alabama Sch Birmingham, Birmingham, AL USA

[8] Univ Florida, Dept Pharmacotherapy & Translat Res, Coll Pharm, Jacksonville, FL USA

[9] Nemours Childrens Specialty Care, Dept Precis Med, Jacksonville, FL USA

[10] Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA

[11] North Dakota State Univ, Dept Pharm Practice, Coll Hlth Profess, Fargo, ND USA

[12] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA

来源：

PHARMACOGENOMICS & PERSONALIZED MEDICINE | 2020年 / 13卷

基金：

美国国家卫生研究院;

关键词：

pharmacogenomics; CYP2C19; clopidogrel; implementation; precision medicine; personalized medicine; clinical pharmacogenomics; CYP2D6; PERSONALIZED MEDICINE; ANTIPLATELET THERAPY; UNIVERSITY; PROGRAM; MODEL; SERVICE; DISSEMINATION; PHARMACISTS; FRAMEWORKS; DELIVERY;

D O I：

10.2147/PGPM.S241599

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Introduction: Clinical adoption of genomic medicine has lagged behind the pace of scientific discovery. Practice-based resources can help overcome implementation challenges. Methods: In 2015, the IGNITE (Implementing GeNomics In pracTicE) Network created an online genomic medicine implementation resource toolbox that was expanded in 2017 to incorporate the ability for users to create targeted implementation guides. This expansion was led by a multidisciplinary team that developed an evidence-based, structured framework for the guides, oversaw the technical process/build, and pilot tested the first guide, CYP2C19-Clopidogrel Testing Implementation. Results: Sixty-five resources were collected from 12 institutions and categorized according to a seven-step implementation framework for the pilot CYP2C19-Clopidogrel Testing Implementation Guide. Five months after its launch, 96 CYP2C19-Clopidogrel Testing Implementation Guides had been created. Eighty percent of the resources most frequently selected by users were created by IGNITE to fill an identified resource gap. Resources most often included in guides were from the test reimbursement (22%), Implementation support gathering (22%), EHR integration (17%), and genetic testing workflow steps (17%). Conclusion: Lessons learned from this implementation guide development process provide insight for prioritizing development of future resources and support the value of collaborative efforts to create resources for genomic medicine implementation.

引用

页码：217 / 226

页数：10

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