Aside from acute renal failure cases, are urinary markers of glomerular and tubular function useful in clinical practice?

被引：5

作者：

Bastard, Jean-Philippe ^{[1
,2
]}

Fellahi, Soraya ^{[1
,2
]}

Regeniter, Axel ^{[3
]}

Capeau, Jacqueline ^{[4
]}

Ronco, Pierre ^{[5
,6
]}

Plaisier, Emmanuelle ^{[5
,6
]}

机构：

[1] Hop Tenon, AP HP, UF Biomarqueurs Inflammatoires & Metab, Serv Biochim & Hormonol, 4 Rue Chine, F-75970 Paris, France

[2] UPMC Univ Paris 06, Sorbonne Univ, INSERM UMRS 938, CDR St Antoine,DHU i2B,IHU ICAN, Paris, France

[3] Med Med Labs, Wolfbachstr 17, CH-8032 Zurich, Switzerland

[4] UPMC Univ Paris 06, Sorbonne Univ, INSERM UMRS 938, CDR St Antoine,IHU ICAN, Paris, France

[5] UPMC Univ Paris 06, Sorbonne Univ, INSERM UMRS 1155, Paris, France

[6] Hop Tenon, AP HP, Serv Nephrol & Dialyse, Paris, France

来源：

CLINICAL BIOCHEMISTRY | 2019年 / 65卷

关键词：

Proteinuria; Glomerular disease; Tubulopathy; ACUTE KIDNEY INJURY; PATTERNS;

D O I：

10.1016/j.clinbiochem.2019.01.006

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The qualitative evaluation of proteinuria represents a crucial diagnostic step in clinical practice for the classification of renal diseases according to glomerular, tubulo-interstitial, mixed injury or related to monoclonal gammopathy. Combined with the quantitative evaluation, it also allows an assessment of the disease's severity and prognosis as well as the response to treatment. The development of the urine protein profile (UPP) combines specific urine protein assays on a urine spot analyzing glomerular protein markers such as albumin, transferrin and immunoglobulin G, and tubular markers such as alpha-1microglobulin and retinol binding protein, to generate a detailed quantitative and qualitative proteinuria assessment. This short overview proposes to illustrate the diagnostic and prognostic usefulness of UPP in different common clinical situations.

引用

页码：1 / 6

页数：6

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