Synthesis of isochromenones and oxepines via Pd-catalyzed cascade cyclization of alkynes and benzynes involving C-H activation

被引：32

作者：

Parthasarathy, Kanniyappan ^{[1
]}

Han, Han ^{[1
]}

Prakash, Chandran ^{[1
]}

Cheng, Chien-Hong ^{[1
]}

机构：

[1] Natl Tsing Hua Univ, Dept Chem, Hsinchu 30013, Taiwan

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 52期

关键词：

HIGHLY EFFICIENT ROUTE; FUSED POLYCYCLIC AROMATICS; REGIOSELECTIVE SYNTHESIS; ARYL HALIDES; 2+2+2 CYCLOADDITION; BICYCLIC ALKENES; TERMINAL ALKYNES; FACILE SYNTHESIS; BOND ACTIVATION; PALLADIUM;

D O I：

10.1039/c2cc31807e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new method for the synthesis of various isochromen-6-ones and phenanthro[1,10-bc]oxepines via a palladium-catalyzed cascade carbocyclization of 2-iodobenzyl-3-phenylpropiolates and 1-iodo-2-(2-(phenylethynyl) benzyloxy) benzenes with arynes is described. The reactions involve interesting biscarbocyclization of alkynes and benzynes and C-H bond activation.

引用

收藏

页码：6580 / 6582

页数：3

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