Keeping 'Trk' of antidepressant actions

被引：14

作者：

Banasr, Mounira ^{[1
,2
]}

Duman, Ronald S. ^{[1
,2
]}

机构：

[1] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06508 USA

[2] Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT 06508 USA

来源：

NEURON | 2008年 / 59卷 / 03期

关键词：

D O I：

10.1016/j.neuron.2008.07.028

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Despite growing evidence that increased brain-derived neurotrophic factor (BDNF) and hippocampal adult neurogenesis are necessary for the behavioral actions of antidepressants in rodents, the cellular mechanisms involved in these effects are still unknown. Li et al. in this issue of Neuron demonstrate that the presence of TrkB, the high-affinity receptor for BDNF, in hippocampal neural progenitor cells is required for the neurogenic and behavioral actions of antidepressant treatments.

引用

页码：349 / 351

页数：3

共 14 条

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