Serum double monoclonal components and hematological malignancies: Only a casual association? Review of 34 cases

被引：21

作者：

Guastafierro, Salvatore ^{[1
]}

Ferrara, Maria Giovanna ^{[1
]}

Sica, Antonello ^{[1
]}

Parascandola, Rita Rosaria ^{[1
]}

Santangelo, Sara ^{[1
]}

Falcone, Umberto ^{[1
]}

机构：

[1] Univ Naples 2, Div Hematol, Naples, Italy

来源：

LEUKEMIA RESEARCH | 2012年 / 36卷 / 10期

关键词：

Double monoclonal component; Hematological malignancies; Immunofixation; Biclonal gammopathy; Diagnosis; BICLONAL GAMMOPATHIES;

D O I：

10.1016/j.leukres.2012.05.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A double monoclonal component (MC) detected in the serum and/or urine represents a very rare occurrence (2-6% of monoclonal gammopathies). In this study, we report 34 patients with double serum MCs, focusing on the associated diseases. The diagnosis was made using high-resolution serum protein electrophoresis and immunofixation. Of the 1214 patients with monoclonal gammopathies, 49 had a double MC but only 34 (2.8%) were included in our study. A double MC was associated with hematological malignancies in 20/34 cases. Based on our experience, a double MC is more often associated with other diseases, especially an oncohematological one. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1274 / 1277

页数：4

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