The Tat protein of human immunodeficiency virus-1 enhances hepatitis C virus replication through interferon gamma-inducible protein-10

被引：24

作者：

Qu, Jing ^{[1
,2
]}

Zhang, Qi ^{[1
,2
]}

Li, Youxing ^{[1
,2
]}

Liu, Weiyong ^{[1
,2
]}

Chen, Lvxiao ^{[1
,2
]}

Zhu, Ying ^{[1
,2
,3
]}

Wu, Jianguo ^{[1
,2
,3
,4
,5
]}

机构：

[1] Wuhan Univ, Zhongnan Hosp, Coll Life Sci, State Key Lab Virol, Wuhan 430072, Peoples R China

[2] Wuhan Univ, Zhongnan Hosp, Chinese French Liver Dis Res Inst, Wuhan 430072, Peoples R China

[3] Wuhan Inst Biotechnol, Wuhan 430075, Peoples R China

[4] Wuhan Univ, State Key Lab Virol, Wuhan 430072, Peoples R China

[5] Wuhan Univ, Coll Life Sci, Wuhan 430072, Peoples R China

来源：

BMC IMMUNOLOGY | 2012年 / 13卷

基金：

中国国家自然科学基金;

关键词：

ACTIVE ANTIRETROVIRAL THERAPY; PERIPHERAL-BLOOD MONOCYTES; HIV-INFECTION; TYPE-1; TAT; FIBROSIS PROGRESSION; MESSENGER-RNA; LIVER-DISEASE; JC VIRUS; IP-10; CHEMOKINE;

D O I：

10.1186/1471-2172-13-15

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: Co-infection with human immunodeficiency virus-1 (HIV-1) and hepatitis C virus (HCV) is associated with faster progression of liver disease and an increase in HCV persistence. However, the mechanism by which HIV-1 accelerates the progression of HCV liver disease remains unknown. Results: HIV-1/HCV co-infection is associated with increased expression of interferon gamma-induced protein-10 (IP-10) mRNA in peripheral blood mononuclear cells (PBMCs). HCV RNA levels were higher in PBMCs of patients with HIV-1/HCV co-infection than in patients with HCV mono-infection. HIV-1 Tat and IP-10 activated HCV replication in a time-dependent manner, and HIV-1 Tat induced IP-10 production. In addition, the effect of HIV-1 Tat on HCV replication was blocked by anti-IP-10 monoclonal antibody, demonstrating that the effect of HIV-1 Tat on HCV replication depends on IP-10. Taken together, these results suggest that HIV-1 Tat protein activates HCV replication by upregulating IP-10 production. Conclusions: HIV-1/HCV co-infection is associated with increased expression of IP-10 mRNA and replication of HCV RNA. Furthermore, both HIV-1 Tat and IP-10 activate HCV replication. HIV-1 Tat activates HCV replication by upregulating IP-10 production. These results expand our understanding of HIV-1 in HCV replication and the mechanism involved in the regulation of HCV replication mediated by HIV-1 during co-infection.

引用

页数：12