Notch-associated lncRNAs profiling circuiting epigenetic modification in colorectal cancer

被引：47
作者：
Emam, Omnia [1 ]
Wasfey, Eman F. [2 ]
Hamdy, Nadia M. [2 ]
机构：
[1] Egyptian Drug Author, Cairo, Egypt
[2] Ain Shams Univ, Fac Pharm, Biochem Dept, Cairo 11566, Egypt
来源：
CANCER CELL INTERNATIONAL | 2022年 / 22卷 / 01期
关键词：
Epigenetics; lncRNAs; Notch; Colorectal cancer; Inflammation; Micro-RNAs; Hallmarks of cancer; LONG NONCODING RNA; PROMOTES CELL-PROLIFERATION; COMPETING ENDOGENOUS RNA; SIGNALING PATHWAY; MESENCHYMAL TRANSITION; POOR-PROGNOSIS; UP-REGULATION; HEPATOCELLULAR-CARCINOMA; REGULATES PROLIFERATION; INHIBITS PROLIFERATION;
D O I：
10.1186/s12935-022-02736-2
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: Colorectal cancer (CRC) is one of the most prevalent digestive cancers, ranking the 2nd cause of cancer-related fatality worldwide. The worldwide burden of CRC is predicted to rise by 60% by 2030. Environmental factors drive, first, inflammation and hence, cancer incidence increase. Main: The Notch-signaling system is an evolutionarily conserved cascade, has role in the biological normal developmental processes as well as malignancies. Long non-coding RNAs (LncRNAs) have become major contributors in the advancement of cancer by serving as signal pathways regulators. They can control gene expression through post-translational changes, interactions with micro-RNAs or down-stream effector proteins. Recent emerging evidence has emphasized the role of lncRNAs in controlling Notch-signaling activity, regulating development of several cancers including CRC. Conclusion: Notch-associated lncRNAs might be useful prognostic biomarkers or promising potential therapeutic targets for CRC treatment. Therefore, here-in we will focus on the role of "Notch-associated lncRNAs in CRC" highlighting "the impact of Notch-associated lncRNAs as player for cancer induction and/or progression."
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页数：24
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