Relationship Between Nerve Fiber Layer Hemorrhages and Outcomes in Central Retinal Vein Occlusion

被引：6

作者：

Au, Adrian ^{[1
]}

Hilely, Assaf ^{[1
,2
]}

Scharf, Jackson ^{[1
]}

Gunnemann, Frederic ^{[1
,3
]}

Wang, Derrick ^{[1
]}

Chehaibou, Ismael ^{[1
]}

Iovino, Claudio ^{[4
]}

Grondin, Christelle ^{[1
]}

Farecki, Marie-Louise ^{[3
]}

Falavarjani, Khalil Ghasemi ^{[5
,6
]}

Phasukkijwatana, Nopasak ^{[7
]}

Battista, Marco ^{[8
]}

Borrelli, Enrico ^{[8
]}

Sacconi, Riccardo ^{[8
]}

Powell, Brittany ^{[9
]}

Hom, Grant ^{[10
]}

Greenlee, Tyler E. ^{[10
]}

Conti, Thais F. ^{[10
]}

Ledesma-Gil, Gerardo ^{[11
]}

Teke, Mehmet Yasin ^{[12
]}

Choudhry, Netan ^{[13
]}

Fung, Adrian T. ^{[14
,15
]}

Krivosic, Valerie ^{[16
]}

Baek, Jiwon ^{[17
]}

Lee, Mee Yon ^{[18
]}

Sugiura, Yoshimi ^{[11
]}

Querques, Giuseppe ^{[8
]}

Peiretti, Enrico ^{[4
]}

Rosen, Richard ^{[9
]}

Lee, Won Ki ^{[19
]}

Yannuzzi, Lawrence A. ^{[11
]}

Zur, Dinah ^{[2
]}

Loewenstein, Anat ^{[2
]}

Pauleikhoff, Daniel ^{[3
]}

Singh, Rishi ^{[10
]}

Modi, Yasha ^{[20
]}

Hubschman, Jean Pierre ^{[1
]}

Ip, Michael ^{[21
]}

Sadda, SriniVas ^{[21
]}

Freund, K. Bailey ^{[11
]}

Sarraf, David ^{[1
,22
]}

机构：

[1] Univ Calif Los Angeles, Stein Eye Inst, 100 Stein Plaza, Los Angeles, CA 90095 USA

[2] Tel Aviv Univ, Ophthalmol Div, Tel Aviv Sourasky Med Ctr, Sackler Fac Med, Tel Aviv, Israel

[3] St Franziskus Hosp, Dept Ophthalmol, Munster, Germany

[4] Univ Cagliari, Dept Surg Sci, Eye Clin, Cagliari, Italy

[5] Iran Univ Med Sci, Rassoul Akram Hosp, Eye Res Ctr, Tehran, Iran

[6] Iran Univ Med Sci, Rassoul Akram Hosp, Eye Dept, Tehran, Iran

[7] Mahidol Univ, Siriraj Hosp, Dept Ophthalmol, Fac Med, Bangkok, Thailand

[8] Univ Vita Salute San Raffaele, Dept Ophthalmol, Osped San Raffaele, Sci Inst, Milan, Italy

[9] New York Eye & Ear Infirm Mt Sinai, Dept Ophthalmol, New York, NY USA

[10] Cleveland Clin, Cole Eye Inst, Cleveland, OH 44106 USA

[11] Vitreous Retina Macula Consultants New York, New York, NY USA

[12] Ankara Ulucanlar Eye Training & Res Hosp, Ophthalmol Dept, Ankara, Turkey

[13] Vitreous Retina Macula Specialists Toronto, Toronto, ON, Canada

[14] Univ Sydney, Westmead & Cent Clin Sch, Discipline Ophthalmol, Sydney, NSW, Australia

[15] Macquarie Univ, Dept Ophthalmol, Fac Med & Hlth Sci, Sydney, NSW, Australia

[16] Univ Paris Diderot, Hop Lariboisiere, AP HP, Sorbonne Paris Cite, Paris, France

[17] Catholic Univ Korea, Bucheon St Marys Hosp, Coll Med, Dept Ophthalmol, Gyeonggi Do, South Korea

[18] Catholic Univ Korea, Uijeongbu St Marys Hosp, Coll Med, Dept Ophthalmol, Gyeonggi Do, South Korea

[19] Nune Eye Hosp, Retina Ctr, Seoul, South Korea

[20] NYU, Sch Med, Dept Ophthalmol, New York, NY USA

[21] Doheny Eye Inst, Doheny Image Reading Ctr, 1355 San Pablo St, Los Angeles, CA 90033 USA

[22] VA Greater Los Angeles Healthcare Syst, Los Angeles, CA USA

来源：

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | 2020年 / 61卷 / 05期

关键词：

central retinal vein occlusion; nerve fiber layer hemorrhages; ischemia; neovascularization; ACUTE MIDDLE MACULOPATHY; SPECTRUM; ANGIOGRAPHY; AREA;

D O I：

10.1167/iovs.61.5.54

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

PURPOSE. To evaluate the depth and pattern of retinal hemorrhage in acute central retinal vein occlusion (CRVO) and to correlate these with visual and anatomic outcomes. METHODS. Retinal hemorrhages were evaluated with color fundus photography and fluorescein angiography at baseline and follow-up. Snellen visual acuity (VA), central foveal thickness (CFT), extent of retinal ischemia, and development of neovascularization were analyzed. RESULTS. 108 eyes from 108 patients were evaluated. Mean age was 63.6 +/- 16.1 years with a predilection for the right eye (73.1%). Average follow-up was 17.2 +/- 19.2 months. Mean VA at baseline was 20/126 and 20/80 at final follow-up. Baseline (P = 0.005) and final VA (P = 0.02) in eyes with perivascular nerve fiber layer (NFL) hemorrhages were significantly worse than in eyes with deep hemorrhages alone. Baseline CFT was greater in the group with perivascular hemorrhages (826 +/- 394 mu m) compared to the group with deep hemorrhages alone (455 +/- 273 mu m, P < 0.001). The 10 disc areas of retinal ischemia was more common in patients with perivascular (80.0%) and peripapillary (31.3%) versus deep hemorrhages alone (16.1%, P < 0.001). Neovascularization of the iris was more common, although this differrence was not significant, in the groups with peripapillary (14.3%) and perivascular (2.0%) NFL versus deep hemorrhages alone (0.0%). CONCLUSIONS. NFL retinal hemorrhages at baseline correlate with more severe forms of CRVO, with greater macular edema, poorer visual outcomes, and greater risk of ischemia and neovascularization. This may be related to the organization of the retinal capillary plexus. The depth and pattern of distribution of retinal hemorrhages in CRVO may provide an easily identifiable early biomarker of CRVO prognosis.

引用

页数：9

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