Diffuse Intrinsic Pontine Gliomas: Treatments and Controversies

被引:11
作者
Bredlau, Amy Lee [1 ,2 ]
Korones, David N. [3 ,4 ]
机构
[1] Med Univ S Carolina, Dept Pediat, Charleston, SC 29425 USA
[2] Med Univ S Carolina, Dept Neurosci, Charleston, SC 29425 USA
[3] Univ Rochester, Dept Pediat, Rochester, NY USA
[4] Univ Rochester, Dept Palliat Care, Rochester, NY USA
来源
ADVANCES IN CANCER RESEARCH, VOL 121 | 2014年 / 121卷
关键词
BRAIN-STEM GLIOMAS; PEDIATRIC-ONCOLOGY-GROUP; CONVECTION-ENHANCED DELIVERY; HYPERFRACTIONATED RADIATION-THERAPY; HIGH-DOSE-CHEMOTHERAPY; HIGH-GRADE GLIOMAS; PHASE-II TRIAL; MOTEXAFIN-GADOLINIUM; MALIGNANT GLIOMAS; TYROSINE KINASE;
D O I
10.1016/B978-0-12-800249-0.00006-8
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Diffuse intrinsic pontine gliomas (DIPGs) are a fairly common pediatric brain tumor, and children with these tumors have a dismal prognosis. They generally are diagnosed within the first decade of life, and due to their location within the pons, these tumors are not surgically resectable. The median survival for children with DIPGs is less than 1 year, in spite of decades of clinical trial development of unique approaches to radiation therapy and chemotherapy. Novel therapies are under investigation for these deadly tumors. As clinicians and researchers make a concerted effort to obtain tumor tissue, the molecular signals of these tumors are being investigated in an attempt to uncover targetable therapies for DIPGs. In addition, direct application of chemotherapies into the tumor (convection-enhanced delivery) is being investigated as a novel delivery system for treatment of DIPGs. Overall, DIPGs require creative thinking and a disciplined approach for development of a therapy that can improve the prognosis for these unfortunate children.
引用
收藏
页码:235 / 259
页数:25
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