The effect of ultraviolet functionalization of titanium on integration with bone

被引：445

作者：

Aita, Hideki ^{[1
]}

Hori, Norio ^{[1
]}

Takeuchi, Masato ^{[2
]}

Suzuki, Takeo ^{[1
]}

Yamada, Masahiro ^{[1
]}

Anpo, Masakazu ^{[2
]}

Ogawa, Takahiro ^{[1
]}

机构：

[1] Univ Calif Los Angeles, LBIS, Jane & Jerry Weintraub Ctr Reconstruct Biotechnol, Div Adv Prosthodont Biomat & Hosp Dent,Sch Dent, Los Angeles, CA 90095 USA

[2] Osaka Prefecture Univ, Dept Appl Chem, Grad Sch Engn, Sakai, Osaka 591, Japan

来源：

BIOMATERIALS | 2009年 / 30卷 / 06期

关键词：

Osseointegration; Photocatalysis; Dental implant; Arthroplasty; Femoral stem; Hydrocarbon; DENTAL IMPLANT FAILURE; FEMORAL-NECK FRACTURES; OSTEOBLAST PROLIFERATION; PROGRESSIVE DEVELOPMENT; EXTRACELLULAR-MATRIX; SURFACE TOPOGRAPHIES; MINERALIZED TISSUE; INTERNAL-FIXATION; HIP FRACTURE; RISK-FACTORS;

D O I：

10.1016/j.biomaterials.2008.11.004

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Titanium implants are used as a reconstructive anchor in orthopedic and dental diseases and problems. Recently, ultraviolet (UV) light-induced photocatalytic activity of titanium has earned considerable and broad interest in environmental and clean-energy sciences. This Study determines whether UV treatment of titanium enhances its osteoconductive capacity. Machined and acid-etched titanium samples were treated with UV for various time periods LIP to 48 h. For both surfaces, UV treatment increased the rates of attachment, spread, proliferation and differentiation of rat bone marrow-derived osteoblasts, as well as the capacity of protein adsorption, by tip to threefold. In vivo histomorphometry in the rat model revealed that new bone formation occurred extensively on UV-treated implants with virtually no intervention by soft tissue, maximizing bone-implant contact tip to nearly 100% at week 4 of healing. An implant biomechanical test revealed that UV treatment accelerated the establishment of implant fixation 4 times. The rates of protein adsorption and cell attachment strongly correlated with the UV dose-responsive atomic percentage of carbon on TiO2, but not with the hydrophilic status. The data indicated that UV light pretreatment of titanium substantially enhances its osteoconductive capacity, in association with UV-catalytic progressive removal of hydrocarbons from the TiO2 surface, suggesting a photofunctionalization of titanium enabling more rapid and complete establishment of bone-titanium integration. 2008 (C) Elsevier Ltd. All rights reserved.

引用

页码：1015 / 1025

页数：11