Bioresorbable Multilayer Photonic Cavities as Temporary Implants for Tether-Free Measurements of Regional Tissue Temperatures

被引：7

作者：

Bai, Wubin ^{[1
,2
]}

Irie, Masahiro ^{[1
,2
]}

Liu, Zhonghe ^{[3
]}

Luan, Haiwen ^{[2
,4
]}

Franklin, Daniel ^{[2
]}

Nandoliya, Khizar ^{[5
]}

Guo, Hexia ^{[1
,2
]}

Zang, Hao ^{[1
]}

Weng, Yang ^{[1
]}

Lu, Di ^{[2
]}

Wu, Di ^{[6
]}

Wu, Yixin ^{[1
,2
]}

Song, Joseph ^{[6
]}

Han, Mengdi ^{[2
]}

Song, Enming ^{[2
,7
]}

Yang, Yiyuan ^{[1
,2
]}

Chen, Xuexian ^{[2
,8
]}

Zhao, Hangbo ^{[2
,9
]}

Lu, Wei ^{[2
]}

Monti, Giuditta ^{[6
]}

Stepien, Iwona ^{[10
]}

Kandela, Irawati ^{[2
]}

Haney, Chad R. ^{[11
]}

Wu, Changsheng ^{[2
]}

Won, Sang Min ^{[12
]}

Ryu, Hanjun ^{[2
]}

Rwei, Alina ^{[2
]}

Shen, Haixu ^{[1
,2
]}

Kim, Jihye ^{[2
,13
]}

Yoon, Hong-Joon ^{[2
,13
]}

Ouyang, Wei ^{[2
]}

Liu, Yihan ^{[1
]}

Suen, Emily ^{[14
]}

Chen, Huang-Yu ^{[2
]}

Okina, Jerry ^{[15
]}

Liang, Jushen ^{[15
]}

Huang, Yonggang ^{[1
,2
,4
,16
]}

Ameer, Guillermo A. ^{[6
,17
,18
,19
]}

Zhou, Weidong ^{[3
]}

Rogers, John A. ^{[1
,2
,4
,5
,6
,17
,18
,19
]}

机构：

[1] Northwestern Univ, Dept Mat Sci & Engn, Evanston, IL 60208 USA

[2] Northwestern Univ, Querrey Simpson Inst Bioelect, Evanston, IL 60208 USA

[3] Univ Texas Arlington, Dept Elect Engn, Arlington, TX 76019 USA

[4] Northwestern Univ, Dept Mech Engn, Evanston, IL 60208 USA

[5] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA

[6] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA

[7] Univ Illinois, Dept Mat Sci & Engn, Urbana, IL 61801 USA

[8] Peking Univ, Acad Adv Interdisciplinary Studies, Beijing, Peoples R China

[9] Univ Southern Calif, Dept Aerosp & Mech Engn, Los Angeles, CA 90089 USA

[10] Northwestern Univ, Ctr Dev Therapeut, Evanston, IL 60208 USA

[11] Northwestern Univ, Ctr Adv Mol Imaging, Evanston, IL 60208 USA

[12] Sungkyunkwan Univ, Dept Elect & Comp Engn, Suwon, South Korea

[13] Sungkyunkwan Univ SKKU, Sch Adv Mat Sci & Engn, Suwon 16419, South Korea

[14] Northwestern Univ, Dept Neurobiol, Evanston, IL 60208 USA

[15] Northwestern Univ, Dept Chem Engn, Evanston, IL 60208 USA

[16] Northwestern Univ, Dept Civil & Environm Engn, Evanston, IL 60208 USA

[17] Northwestern Univ, Dept Elect Engn & Comp Sci, Evanston, IL 60208 USA

[18] Northwestern Univ, Feinberg Sch Med, Northwestern Med, Evanston, IL 60208 USA

[19] Northwestern Univ, Ctr Adv Regenerat Engn, Evanston, IL 60208 USA

来源：

BME FRONTIERS | 2021年 / 2021卷

基金：

美国国家科学基金会;

关键词：

BODY-TEMPERATURE; OPTICAL-PROPERTIES; SILICON; SENSORS; COEFFICIENT; WIRELESS; SYSTEMS; DEVICES; SLEEP;

D O I：

10.34133/2021/8653218

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Objective and Impact Statement. Real-time monitoring of the temperatures of regional tissue microenvironments can serve as the diagnostic basis for treating various health conditions and diseases. Introduction. Traditional thermal sensors allow measurements at surfaces or at near-surface regions of the skin or of certain body cavities. Evaluations at depth require implanted devices connected to external readout electronics via physical interfaces that lead to risks for infection and movement constraints for the patient. Also, surgical extraction procedures after a period of need can introduce additional risks and costs. Methods. Here, we report a wireless, bioresorbable class of temperature sensor that exploits multilayer photonic cavities, for continuous optical measurements of regional, deep-tissue microenvironments over a timeframe of interest followed by complete clearance via natural body processes. Results. The designs decouple the influence of detection angle from temperature on the reflection spectra, to enable high accuracy in sensing, as supported by in vitro experiments and optical simulations. Studies with devices implanted into subcutaneous tissues of both awake, freely moving and asleep animal models illustrate the applicability of this technology for in vivo measurements. Conclusion. The results demonstrate the use of bioresorbable materials in advanced photonic structures with unique capabilities in tracking of thermal signatures of tissue microenvironments, with potential relevance to human healthcare.

引用

页数：14

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