The Preeminent Role of Childhood Abuse and Neglect in Vulnerability to Major Psychiatric Disorders: Toward Elucidating the Underlying Neurobiological Mechanisms

被引：40

作者：

Nemeroff, Charles B. ^{[1
]}

Binder, Elisabeth ^{[2
]}

机构：

[1] Univ Miami, Miller Sch Med, Miami, FL 33136 USA

[2] Max Planck Inst Psychiat, D-80804 Munich, Germany

来源：

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY | 2014年 / 53卷 / 04期

关键词：

CORTICOTROPIN-RELEASING-FACTOR; DNA METHYLATION; EMOTIONAL BRAIN; LIFE STRESS; DEPRESSION; GENE; MODERATION; RECEPTOR; TRAUMA; RISK;

D O I：

10.1016/j.jaac.2014.02.004

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

引用

页码：395 / 397

页数：3

共 21 条

[1]

Barfield RT, 2014, GENET EPIDEMIOL

[2] Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults [J].

Binder, Elisabeth B. ;

Bradley, Rebekah G. ;

Liu, Wei ;

Epstein, Michael P. ;

Deveau, Todd C. ;

Mercer, Kristina B. ;

Tang, Yilang ;

Gillespie, Charles F. ;

Heim, Christine M. ;

Nemeroff, Charles B. ;

Schwartz, Ann C. ;

Cubells, Joseph F. ;

Ressler, Kerry J. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2008, 299 (11) :1291-1305

[3] Influence of child abuse on adult depression - Moderation by the corticotropin-releasing hormone receptor gene [J].

Bradley, Rebekah G. ;

Binder, Elisabeth B. ;

Epstein, Michael P. ;

Tang, Yilang ;

Nair, Hemu P. ;

Liu, Wei ;

Gillespie, Charles F. ;

Berg, Tiina ;

Evces, Mark ;

Newport, D. Jeffrey ;

Stowe, Zachary N. ;

Heim, Christine M. ;

Nemeroff, Charles B. ;

Schwartz, Ann ;

Cubells, Joseph F. ;

Ressler, Kerry J. .

ARCHIVES OF GENERAL PSYCHIATRY, 2008, 65 (02) :190-200

[4] Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene [J].

Caspi, A ;

Sugden, K ;

Moffitt, TE ;

Taylor, A ;

Craig, IW ;

Harrington, H ;

McClay, J ;

Mill, J ;

Martin, J ;

Braithwaite, A ;

Poulton, R .

SCIENCE, 2003, 301 (5631) :386-389

[5] Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: Implications for the pathophysiology of mood and anxiety disorders [J].

Coplan, JD ;

Andrews, MW ;

Rosenblum, LA ;

Owens, MJ ;

Friedman, S ;

Gorman, JM ;

Nemeroff, CB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (04) :1619-1623

[6]

Freud Sigmund., 1962, The Standard Edition of the Complete Psychological Works of Sigmund Freud, V3

[7] Early Life Stress Combined with Serotonin 3A Receptor and Brain-Derived Neurotrophic Factor Valine 66 to Methionine Genotypes Impacts Emotional Brain and Arousal Correlates of Risk for Depression [J].

Gatt, Justine M. ;

Nemeroff, Charles B. ;

Schofield, Peter R. ;

Paul, Robert H. ;

Clark, C. Richard ;

Gordon, Evian ;

Williams, Leanne M. .

BIOLOGICAL PSYCHIATRY, 2010, 68 (09) :818-824

[8] IMPACT OF THE HTR3A GENE WITH EARLY LIFE TRAUMA ON EMOTIONAL BRAIN NETWORKS AND DEPRESSED MOOD [J].

Gatt, Justine M. ;

Williams, Leanne M. ;

Schofield, Peter R. ;

Dobson-Stone, Carol ;

Paul, Robert H. ;

Grieve, Stuart M. ;

Clark, C. Richard ;

Gordon, Evian ;

Nemeroff, Charles B. .

DEPRESSION AND ANXIETY, 2010, 27 (08) :752-759

[9] A cell epigenotype specific model for the correction of brain cellular heterogeneity bias and its application to age, brain region and major depression [J].

Guintivano, Jerry ;

Aryee, Martin J. ;

Kaminsky, Zachary A. .

EPIGENETICS, 2013, 8 (03) :290-302

[10] Depression, Antidepressants, and Neurogenesis: A Critical Reappraisal [J].

Hanson, Nicola D. ;

Owens, Michael J. ;

Nemeroff, Charles B. .

NEUROPSYCHOPHARMACOLOGY, 2011, 36 (13) :2589-2602

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