AEG-1/MTDH/LYRIC: Clinical Significance

被引：74
作者：
Sarkar, Devanand [1 ,2 ,3 ]
Fisher, Paul B. [1 ,2 ,3 ]
机构：
[1] Virginia Commonwealth Univ, Sch Med, Dept Human & Mol Genet, Richmond, VA 23284 USA
[2] Virginia Commonwealth Univ, Sch Med, VCU Inst Mol Med, Richmond, VA USA
[3] Virginia Commonwealth Univ, Sch Med, VCU Massey Canc Ctr, Richmond, VA USA
来源：
AEG-1/MTDH/LYRIC IMPLICATED IN MULTIPLE HUMAN CANCERS | 2013年 / 120卷
关键词：
ASTROCYTE-ELEVATED GENE-1; RENAL-CELL CARCINOMA; POOR-PROGNOSIS; CANCER PROGRESSION; BREAST-CANCER; AEG-1; METADHERIN; EXPRESSION; OVEREXPRESSION; PROTEIN;
D O I：
10.1016/B978-0-12-401676-7.00002-4
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
"Gain-of-function" and "loss-of-function" studies in human cancer cells and analysis of a transgenic mouse model have convincingly established that AEG-1/MTDH/LYRIC performs a seminal role in regulating proliferation, invasion, angiogenesis, metastasis, and chemoresistance, the salient defining hallmarks of cancer. These observations are strongly buttressed by clinicopathologic correlations of AEG-1/MTDH/LYRIC expression in a diverse array of cancers distinguishing AEG-1/MTDH/LYRIC as an independent biomarker for highly aggressive metastatic disease with poor prognosis. AEG-1/MTDH/LYRIC has been shown to be a marker predicting response to chemotherapy, and serum anti-AEG-1/MTDH/LYRIC antibody titer also serves as a predictor of advanced stages of aggressive cancer. However, inconsistent findings have been reported regarding the localization of AEG-1/MTDH/LYRIC protein in the nucleus or cytoplasm of cancer cells and the utility of nuclear or cytoplasmic AEG-1/MTDH/LYRIC to predict the course and prognosis of disease. This chapter provides a comprehensive analysis of the existing literature to emphasize the common and conflicting findings relative to the clinical significance of AEG-1/MTDH/LYRIC in cancer.
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收藏
页码：39 / 74
页数：36
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