Alternative Splicing in Angiogenesis

被引：97

作者：

Bowler, Elizabeth ^{[1
]}

Oltean, Sebastian ^{[1
]}

机构：

[1] Univ Exeter, Coll Med & Hlth, Med Sch, Inst Biomed & Clin Sci, Exeter EX4 4PY, Devon, England

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 09期

基金：

英国生物技术与生命科学研究理事会;

关键词：

alternative splicing; angiogenesis; VEGF; VEGFR; NRP; FGFR; vasohibin; HIF-1; angiopoietin; ENDOTHELIAL GROWTH-FACTOR; PAS DOMAIN PROTEIN; FACTOR-RECEPTOR; STRUCTURAL BASIS; HEPARIN-BINDING; TUMOR-GROWTH; FACTOR SRSF1; FACTOR-A; SIGNAL-TRANSDUCTION; GENOMIC STRUCTURE;

D O I：

10.3390/ijms20092067

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alternative splicing of pre-mRNA allows the generation of multiple splice isoforms from a given gene, which can have distinct functions. In fact, splice isoforms can have opposing functions and there are many instances whereby a splice isoform acts as an inhibitor of canonical isoform function, thereby adding an additional layer of regulation to important processes. Angiogenesis is an important process that is governed by alternative splicing mechanisms. This review focuses on the alternative spliced isoforms of key genes that are involved in the angiogenesis process; VEGF-A, VEGFR1, VEGFR2, NRP-1, FGFRs, Vasohibin-1, Vasohibin-2, HIF-1, Angiopoietin-1 and Angiopoietin-2.

引用

页数：27

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