Genetic Diversity of HIV-1 in Tunisia

被引：1

作者：

El Moussi, Awatef ^{[1
,2
,3
]}

Thomson, Michael M. ^{[4
]}

Delgado, Elena ^{[4
]}

Teresa Cuevas, Maria ^{[4
]}

Nasr, Majda ^{[1
]}

Abid, Salma ^{[1
,2
]}

Kacem, Mohamed Ali Ben Hadj ^{[1
,2
]}

Tiouiri, Hanene Benaissa ^{[5
]}

Letaief, Amel ^{[6
]}

Chakroun, Mohamed ^{[7
]}

Ben Jemaa, Mounir ^{[8
]}

Hamdouni, Hayet ^{[3
,9
]}

Dellagi, Rafla Tej ^{[9
]}

Kheireddine, Khaled ^{[3
,10
]}

Boutiba, Ilhem ^{[1
,2
]}

Perez-Alvarez, Lucia ^{[4
]}

Slim, Amine ^{[1
,2
]}

机构：

[1] Charles Nicolle Univ Hosp, Microbiol Lab, Virol Unit, Blvd 9 Avril, Tunis 1006, Tunisia

[2] Fac Med Tunis, Lab Res Resistance Antibiot, Tunis, Tunisia

[3] Global Fund Fight AIDS TB & Malaria, Geneva, Switzerland

[4] Inst Salud Carlos III, Ctr Nacl Microbiol, HIV Biol & Variabil Unit, Madrid, Spain

[5] Rabta Univ Hosp, Dept Infect Dis, Tunis, Tunisia

[6] Farhat Hached Univ Hosp, Dept Infect Dis, Sousse, Tunisia

[7] Fatouma Bourguiba Univ Hosp, Dept Infect Dis, Monastir, Tunisia

[8] Hedi Chaker Univ Hosp Sfax, Dept Infect Dis, Sfax, Tunisia

[9] Minist Hlth, Primary Hlth Care Directory DSSB, Tunis, Tunisia

[10] Natl Off Family & Populat, Tunis, Tunisia

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2017年 / 33卷 / 01期

关键词：

Tunisia; HIV-1; genetic diversity; recombinant forms; unique recombinant forms; TYPE-1; MUTATIONS; SUBTYPES; MOROCCO; AFRICA;

D O I：

10.1089/aid.2016.0164

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this study, the genetic diversity of HIV-1 in Tunisia was analyzed. For this, 193 samples were collected in different regions of Tunisia between 2012 and 2015. A protease and reverse transcriptase fragment were amplified and sequenced. Phylogenetic analyses were performed through maximum likelihood and recombinationwas analyzed by bootscanning. Six HIV-1 subtypes (B, A1, G, D, C, and F2), 5 circulating recombinant forms (CRF02_AG, CRF25_cpx, CRF43_02G, CRF06_cpx, and CRF19_cpx), and 11 unique recombinant forms were identified. Subtype B (46.4%) and CRF02_AG (39.4%) were the predominant genetic forms. A group of 44 CRF02_AG sequences formed a distinct Tunisian cluster, which also included four viruses from western Europe. Nine viruses were closely related to isolates collected in other African or in European countries. In conclusion, a high HIV-1 genetic diversity is observed in Tunisia and the local spread of CRF02_AG is first documented in this country.

引用

页码：77 / 81

页数：5

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