Phospholipase D structure and regulation

被引：100
作者：
Frohman, MA [1 ]
Morris, AJ
机构：
[1] SUNY Stony Brook, Dept Pharmacol Sci, Stony Brook, NY 11794 USA
[2] SUNY Stony Brook, Inst Cell & Dev Biol, Stony Brook, NY 11794 USA
来源：
CHEMISTRY AND PHYSICS OF LIPIDS | 1999年 / 98卷 / 1-2期
关键词：
phospholipase D; PLD1; PLD2; ARF; rho; protein kinase C;
D O I：
10.1016/S0009-3084(99)00025-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The recent identification of cDNA clones for phospholipase D has opened the door to new types of investigations into its structure and regulation. PLD activity has been found to be encoded by at least two different genes that contain catalytic domains that relate their mechanism of action to phosphodiesterases. In vivo roles for PLD suggest that it may be important for multiples steps in regulated secretion and membrane biogenesis. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
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收藏
页码：127 / 140
页数：14
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