Serum uromodulin is a novel renal function marker in the Japanese population

被引:6
作者
Usui, Ryosuke [1 ]
Ogawa, Tetsuya [2 ]
Takahashi, Hideo [3 ]
Iwasaki, Chihiro [1 ]
Koike, Minako [1 ]
Morito, Taku [4 ]
Hatano, Michiyasu [4 ]
Nitta, Kosaku [5 ]
机构
[1] Tokyo Womens Med Univ, Yachiyo Med Ctr, Dept Med, Div Nephrol, 477-96 Owadashinden, Chiba 2768524, Japan
[2] Tokyo Womens Med Univ, Med Ctr East, Dept Med, Tokyo, Japan
[3] Minami Akatsuka Clin, Ibaraki, Japan
[4] Yokohama Rosai Hosp, Div Nephrol, Dept Med, Yokohama, Kanagawa, Japan
[5] Tokyo Womens Med Univ, Kidney Ctr, Dept Med, Tokyo, Japan
关键词
Uromodulin; Tamm-horsfall protein; Kidney function; CKD; Biomarker; GLOMERULAR-FILTRATION-RATE; TAMM-HORSFALL GLYCOPROTEIN; CYSTATIN-C; KIDNEY-DISEASE; CREATININE; RISK; ASSOCIATION; MORTALITY; BIOMARKER; INJURY;
D O I
10.1007/s10157-020-01964-y
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Background Uromodulin, also known as Tamm-Horsfall protein, is the most abundant protein in urine. It has recently been reported that uromodulin exists in a small amount in blood and that its concentration correlates with the estimated glomerular filtration rate (eGFR). Methods First, we generated anti-human uromodulin mouse monoclonal antibodies (mAb(s)) and established a specific enzyme-linked immunosorbent assay (ELISA) for uromodulin. We then performed an observational clinical study to determine if there was a correlation between serum uromodulin concentration and estimates of kidney function and whether the serum uromodulin value could be a biomarker in clinical nephrology. The clinical study included 308 patients with and without chronic kidney disease and healthy volunteers. Serum concentrations of creatinine, cystatin C, and uromodulin were measured and correlations were sought between the eGFR calculated from the creatinine and cystatin C levels and the serum uromodulin concentration. Results There was a good correlation between the serum uromodulin concentration and the eGFR value calculated from the creatinine (r = 0.76) and cystatin C (r = 0.79) levels. The mean serum uromodulin level in the group with an eGFR > 90 mL/min/1.73 m(2)calculated using cystatin C was significantly higher than that in the group with an eGFR of 80-89 mL/min/1.73 m(2). Conclusions The serum uromodulin measurement could be a useful biomarker for identification of patients with early deterioration of kidney function.
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页码:28 / 36
页数:9
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