High-Resolution CT Findings of Mycobacterium avium-intracellulare Complex Pulmonary Disease: Correlation with Pulmonary Function Test Results

被引:41
作者
Song, Jong Woon [1 ,2 ]
Koh, Won-Jung [3 ]
Lee, Kyung Soo [2 ]
Lee, Ji Young [1 ,2 ]
Chung, Myung Jin [1 ,2 ]
Kim, Tale Sung [1 ]
Kwon, O. Jung [3 ]
机构
[1] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Radiol, Seoul 135710, South Korea
[2] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Ctr Imaging Sci, Seoul 135710, South Korea
[3] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Pulm & Crit Care Med,Dept Med, Seoul 135710, South Korea
关键词
bronchiectasis; bronchiolitis; CT; high-resolution CT; lung infections; Mycobacterium avium-intracellulare complex; pulmonary function tests;
D O I
10.2214/AJR.07.3505
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
OBJECTIVE. The purpose of our study was to analyze the high-resolution CT findings of the nodular bronchiectatic form of Mycobacterium avium-intracellulare complex (MAC) pulmonary disease and to correlate the extent of high-resolution CT findings with pulmonary function test (PFT) results. MATERIALS AND METHODS. From January 2005 through December 2005, we identified 47 patients (mean age, 58 +/- 13 years age range, 24-72 years; male-female ratio, 11:36) with the nodular bronchiectatic form of MAC pulmonary disease who underwent both high-resolution CT and PFTs. High-resolution CT findings were reviewed retrospectively in terms of the presence and extent of bronchiectasis, cellular or inflammatory bronchiolitis (centrilobular small nodules and tree-in-bud signs), cavity, nodule, and other findings. The extent of the abnormalities seen on high-resolution CT was scored by modifying the cystic fibrosis scoring system proposed by Helbich and coworkers. The scores were correlated with PFT results using Spearman's correlation coefficient. RESULTS. On high-resolution CT, the three most frequently observed patterns of parenchymal abnormalities were, in decreasing order of frequency, cellular bronchiolitis (n = 47, 100%), bronchiectasis (n = 46, 98%), and consolidation (n = 27, 57%). The total CT score showed a significant correlation with the residual volume-total lung capacity (RV/TLC) ratio (r = 0.572, p < 0.001), forced expiratory volume in 1 second (FEV1) value (r = -0.426, p = 0.003), forced vital capacity (FVC) value (r = -0.360, p = 0.013), peak expiratory flow value (r = -0.352, p = 0.015), and peak expiratory flow between 25% and 75% of the forced vital capacity (FEF25-75%) (r = -0.289, p = 0.049). CONCLUSION. CT scoring of pulmonary abnormalities correlates with measures of functional impairment in patients with MAC pulmonary disease.
引用
收藏
页码:W160 / W166
页数:7
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