The panacea for cardiovascular diseases: The role of statins in the management of heart failure

被引：2

作者：

Celik, Turgay ^{[1
]}

Iyisoy, Atila ^{[1
]}

Yuksel, U. Cagdas ^{[2
]}

Isik, Ersoy ^{[1
]}

机构：

[1] Gulhane Mil Med Acad, Sch Med, Dept Cardiol, Etlik, Turkey

[2] Sarikamis Army Dist Hosp, Dept Cardiol Sarikamis, Sarikamis, Turkey

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2008年 / 129卷 / 03期

关键词：

chronic heart failure; statins; cardiovascular mortality;

D O I：

10.1016/j.ijcard.2007.06.045

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The data obtained from retrospective studies have indicated that patients with chronic heart failure (CHF) on statin treatment have good cardiovascular outcomes, in both ischemic and nonischemic dilated cardiomyopathy. There is an ongoing debate about whether the effects of statins on ubiquinone and cholesterol levels might have a negative impact in patients with CHF. We believe that 3 large scale ongoing randomized clinical trials (the GISSI-HF, CORONA and UNIVERSE) will come to end the debate over the safety and efficacy of statin treatment in patients with CHF. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：422 / 423

页数：2

共 18 条

[1] HMG-CoA reductase inhibitors reduce MMP-9 secretion by macrophages [J].

Bellosta, S ;

Via, D ;

Canavesi, M ;

Pfister, P ;

Fumagalli, R ;

Paoletti, R ;

Bernini, F .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1998, 18 (11) :1671-1678

[2] Prognostic significance of serum cholesterol levels in patients with idiopathic dilated cardiomyopathy [J].

Christ, M ;

Klima, T ;

Grimm, W ;

Mueller, HH ;

Maisch, B .

EUROPEAN HEART JOURNAL, 2006, 27 (06) :691-699

[3] Effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells [J].

Hernández-Perera, O ;

Pérez-Sala, D ;

Navarro-Antolín, J ;

Sánchez-Pascuala, R ;

Hernández, G ;

Díaz, C ;

Lamas, S .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (12) :2711-2719

[4] Statins and chronic heart failure: Do we need a large-scale outcome trial? [J].

Krum, H ;

McMurray, JJ .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2002, 39 (10) :1567-1573

[5] Statins and symptomatic chronic systolic heart failure: A post-hoc analysis of 5010 patients enrolled in Val-HeFT [J].

Krum, Henry ;

Latini, Roberto ;

Maggioni, Aldo P. ;

Anand, Inder ;

Masson, Serge ;

Carretta, Elisa ;

Ingrilli, Franco ;

Pettinati, Giacinto ;

Glazer, Robert ;

Tognoni, Gianni ;

Cohn, Jay .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2007, 119 (01) :48-53

[6]

Laufs U, 2004, Z KARDIOL, V93, P103, DOI 10.1007/s00392-004-1005-0

[7] Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors [J].

Laufs, U ;

La Fata, V ;

Plutzky, J ;

Liao, JK .

CIRCULATION, 1998, 97 (12) :1129-1135

[8] Drug Insight: statins for nonischemic heart failure - Evidence and potential mechanisms [J].

Lipinski, Michael J. ;

Abbate, Antonio ;

Fuster, Valentin ;

Vetrovec, George W. .

NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE, 2007, 4 (04) :196-205

[9] Simvastatin inhibits cardiac hypertrophy and angiotensin-converting enzyme activity in rats with aortic stenosis [J].

Luo, JD ;

Zhang, WW ;

Zhang, GP ;

Guan, JX ;

Chen, X .

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 1999, 26 (11) :903-908

[10] Statin-sensitive dysregulated AT1 receptor function and density in hypercholesterolemic men [J].

Nickenig, G ;

Bäumer, AT ;

Temur, Y ;

Kebben, D ;

Jockenhövel, F ;

Böhm, M .

CIRCULATION, 1999, 100 (21) :2131-2134

← 1 2 →