Intragenic breakpoint within RAD51L1 in a t(6;14)(p21.3;q24) of a pulmonary chondroid hamartoma

被引：11

作者：

Blank, C

Schoenmakers, EFPM

Rogalla, P

Huys, EHLPG

van Rijk, AAF

Drieschner, N

Bullerdiek, J

机构：

[1] Univ Bremen, Ctr Human Genet, D-28359 Bremen, Germany

[2] Univ Nijmegen, Med Ctr, Dept Human Genet, Nijmegen, Netherlands

来源：

CYTOGENETICS AND CELL GENETICS | 2001年 / 95卷 / 1-2期

关键词：

D O I：

10.1159/000057011

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Rearrangements involving chromosome region 14q23-->q24 represent a main cytogenetic subgroup in a variety of benign solid tumors. Recently, in uterine leiomyomas containing the classical t(12;14)(q15;q23-->q24), the primary chromosome 14 target gene was identified as the protein kinase-encoding gene RAD51L1. In this report we show that RAD51L1 is also involved in the frequently ocurring t(6;14) (p21;q23-->q24) in pulmonary chondroid hamartomas. Copyright (C) 2002 S. Karger AG, Basel.

引用

页码：17 / 19

页数：3

共 11 条

[1] Truncated and chimeric HMGI-C genes induce neoplastic transformation of NIH3T3 murine fibroblasts [J].