Pd(OAc)2-catalyzed regioselective aromatic C-H bond fluorination

被引：86

作者：

Lou, Shao-Jie ^{[1
]}

Xu, Dan-Qian ^{[1
]}

Xia, Ai-Bao ^{[1
]}

Wang, Yi-Feng ^{[1
]}

Liu, Yun-Kui ^{[1
]}

Du, Xiao-Hua ^{[1
]}

Xu, Zhen-Yuan ^{[1
]}

机构：

[1] Zhejiang Univ Technol, State Key Lab Breeding Base Green Chem Synth Tech, Catalyt Hydrogenat Res Ctr, Hangzhou 310014, Zhejiang, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 55期

关键词：

COPPER-MEDIATED FLUORINATION; REGIOSPECIFIC SYNTHESIS; REDUCTIVE ELIMINATION; ELECTROSPRAY MASS; ARYL; FUNCTIONALIZATION; MECHANISM; CATALYSIS;

D O I：

10.1039/c3cc42220h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel Pd(OAc)(2)-NFSI-TFA system was developed for the highly selective ortho-monofluorination directed by diverse aryl-N-heterocyclic directing groups e. g., quinoxaline, pyrazole, benzo[d]oxazole, and pyrazine derivatives. A Pd(II/IV) catalytic cycle was proposed based on the ESI-MS/MS studies.

引用

页码：6218 / 6220

页数：3

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