Cu(II) Schiff Base Complex as a Highly Efficient Catalyst for the Synthesis of Polyhydroquinoline Derivatives via Hantzsch Condensation in Water

被引：6

作者：

Vahdat, Seyed Mohammad ^{[1
]}

机构：

[1] Islamic Azad Univ, Ayatollah Amoli Branch, Dept Chem, Amol, Iran

来源：

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING | 2013年 / 16卷 / 10期

关键词：

Cu(II) schiff-base catalyst; hantzsch condensation; polyhydroquinoline; water solvent; ONE-POT SYNTHESIS; IONIC LIQUID; OXIDATION; 1,4-DIHYDROPYRIDINES; ALCOHOLS;

D O I：

10.2174/13862073113169990003

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

In the present study, Cu(II) Schiff-base complex is introduced as a highly efficient and green solid catalyst for the unsymmetrical Hantzsch condensation through a four-component coupling of various aldehydes, dimedone, ethyl acetoacetate and ammonium acetate to form polyhydroquinoline derivatives in good to excellent yields. This reaction was carried out in the presence of 1 mol% of catalysts in water at room temperature. The reusability of the catalysts was demonstrated by a five-run test. Remarkable features of this new procedure are cleaner reaction profiles, shorter reactiontimes, simple experimental and work-up procedures.

引用

页码：782 / 787

页数：6

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