NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound

被引：68

作者：

Wedlock, Louise E. ^{[1
,2
]}

Kilburn, Matt R. ^{[2
]}

Liu, Rong ^{[2
]}

Shaw, Jeremy A. ^{[2
]}

Berners-Price, Susan J. ^{[1
,3
]}

Farrell, Nicholas P. ^{[1
,4
]}

机构：

[1] Griffith Univ, Inst Glyc, Gold Coast, Qld 4222, Australia

[2] Univ Western Australia, Ctr Microscopy Characterisat & Anal, Crawley, WA 6009, Australia

[3] Univ Western Australia, Sch Chem & Biochem, Crawley, WA 6009, Australia

[4] Virginia Commonwealth Univ, Dept Chem, Richmond, VA 23284 USA

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 62期

基金：

美国国家卫生研究院; 澳大利亚研究理事会;

关键词：

CELLULAR ACCUMULATION; LINKING LIGANDS; SINGLE CELLS; CISPLATIN; COMPLEXES; CARCINOMA; LOCALIZATION; N,N'-BIS(AMINOALKYL)-1,4-DIAMINOANTHRAQUINONES; MICROSCOPY; TRAFFICKING;

D O I：

10.1039/c3cc42098a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Simultaneous multi-element imaging using NanoSIMS (nano-scale secondary ion mass spectrometry), exploiting the novel combination of Pt-195 and N-15 in platinum-am(m)ine antitumour drugs, provides information on the internalisation and subcellular localisation of both metal and ligands, and allows identification of ligand exchange.

引用

页码：6944 / 6946

页数：3

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