Preparation and in vitro evaluation of enteric-coated tablets of rosiglitazone sodium

被引：21

作者：

Pan, Xin-mei ^{[1
]}

Li, Jie ^{[1
]}

Gan, Run ^{[1
]}

Hu, Xiang-nan ^{[1
]}

机构：

[1] Chongqing Med Univ, Sch Pharm, Chongqing 400016, Peoples R China

来源：

SAUDI PHARMACEUTICAL JOURNAL | 2015年 / 23卷 / 05期

关键词：

Enteric-coated tablet; Release tests; Polyvinylpyrrolidone (PVP); Hydroxypropyl cellulose; MALEATE;

D O I：

10.1016/j.jsps.2015.02.018

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of this study was to prepare the rosiglitazone sodium enteric-coated tablets and investigate its release rate. The rosiglitazone sodium enteric-coated tablet was prepared by single punch tablet press using substituted hydroxypropyl cellulose and polyvinylpyrrolidone (PVP). The release rate from the enteric-coated tablet of rosiglitazone sodium was evaluated. The release rate study showed that few rosiglitazone sodium was released from enteric coated formulation within 2 h in simulated gastric juice, while it released more than 80% of the labeled amount in 30 min in simulated intestinal juice. The preparing method of rosiglitazone sodium enteric-coated tablets was simple and had a good reproducibility. The release condition and determined methods could be used for the routine determinations of rosiglitazone sodium enteric-coated tablets. (C) 2015 The Authors. Production and hosting by Elsevier B.V.

引用

页码：581 / 586

页数：6