In vitro activities of Strychnos alkaloids and extracts against Plasmodium falciparum

被引：59
作者：
Frederich, M
Hayette, MP
Tits, M
De Mol, P
Angenot, L
机构：
[1] CHU Sart Tilman, Inst Pharm, Lab Pharmacognosie, B-4000 Liege, Belgium
[2] CHU Sart Tilman, Inst Pathol, Lab Microbiol Med, B-4000 Liege, Belgium
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 09期
关键词：
D O I：
10.1128/AAC.43.9.2328
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The in vitro antimalarial activities of 46 alkaloids and extracts from Strychnos species were evaluated. Two types of quasidimeric alkaloids exhibit high and selective activities against Plasmodium. Strychnopentamine and isostrychnopentamine were active against chloroquine-sensitive and -resistant strains (50% inhibitory concentration [IC50] approximate to 0.15 mu M), while dihydrousamharensine exhibited a 30-fold higher activity against the chloroquine-resistant strain (IC50 = 0.03 mu M) than it did against the chloroquine-sensitive strain.
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页码：2328 / 2331
页数：4
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