Newly identified ADAR-mediated A-to-I editing positions as a tool for ALS research

被引：26
作者：
Kwak, Shin [1 ]
Nishimoto, Yoshinori [1 ,2 ]
Yamashita, Takenari [1 ]
机构：
[1] Univ Tokyo, Grad Sch Med, Dept Neurol, Bunkyo Ku, Tokyo 1138655, Japan
[2] Keio Univ, Grad Sch Med, Dept Neurol, Shinjuku Ku, Tokyo, Japan
来源：
RNA BIOLOGY | 2008年 / 5卷 / 04期
关键词：
RNA editing; ADAR; GluR2; ALS; cell death;
D O I：
10.4161/rna.6925
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
5HT, 5-hytroxytryptamine (serotonine); ADAR, adenosine deaminase acting on RNA; ALS, amyotrophic lateral sclerosis; AMPA, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; BLCAP, bladder cancer associated protein; CYFIP2, cytoplasmic fragile X mental retardation protein interacting protein 2; DRPLA, dentatorubro-pallidoluysian atrophy; FLNA, filamin A; hnRNP, heterogeneous nuclear ribonucleoprotein; IGFBP7, insulin-like growth factor binding protein 7; IP, immunoprecipitation; MND, motor neuron disease; PBP, progressive bulbar palsy; RNAi, RNA interference; SBMA, spinal and bulbar muscular atrophy; SCD, spinocerebellar degeneration; SOD I, Cu/Zn superoxide dismutase; TDP-43, transactivation response region DNA-biding protein 43
引用
收藏
页码：193 / 197
页数：5
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