Intraoperative hypothermia is a significant prognostic predictor of radical cystectomy especially for stage II muscle-invasive bladder cancer

被引:23
作者
Morozumi, Kento [1 ]
Mitsuzuka, Koji [2 ]
Takai, Yuki [1 ]
Katsumata, Yuki [1 ]
Kuromoto, Akito [1 ]
Hoshi, Senji [1 ]
Numahata, Kenji [1 ]
Arai, Yoichi [2 ]
机构
[1] Yamagata Prefectural Cent Hosp, Dept Urol, 1800 Aoyagi, Oaza, Yamagata 9902292, Japan
[2] Tohoku Univ, Grad Sch Med, Dept Urol, Sendai, Miyagi, Japan
关键词
complication; intraoperative hypothermia; muscle-invasive bladder cancer; prognosis; recurrence; NEUTROPHIL-LYMPHOCYTE RATIO; OVARIAN-CANCER; COMPLICATIONS; SURGERY; RISK; NORMOTHERMIA; INFECTION; CARCINOMA; SURVIVAL;
D O I
10.1097/MD.0000000000013962
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The objective of this study was to evaluate intraoperative hypothermia as a predictor of complication and prognosis in patients with muscle-invasive bladder cancer treated with radical cystectomy. The data of 124 patients treated with radical cystectomy for muscle-invasive bladder cancer in our department, from 2003 to 2016, were retrospectively collected. The patients were divided into 2 groups according to the lowest intraoperative deep body temperature, that is, the hypothermia group (<96.8 degrees F) and the normothermia group (>= 96.8 degrees F). Preoperative and intraoperative variables were compared among the 2 groups, and factors associated with complications, recurrences, and survivals were analyzed. Sixty-eight (54.8%) of the 124 patients presented intraoperative hypothermia. There was no significant difference in the patient's characteristics between the 2 groups. Postoperative complications (Clavien-Dindo <= III) of any types occurred in 15 patients (22.1%) in the hypothermia group, as compared with 8 patients (14.3%) in the normothermia group (P=.27). The hypothermia group had a higher pathologic stage (P=.029) and a higher recurrence rate within 12 months (P=.013), as compared with the normothermia group. Intraoperative hypothermia was an independent prognostic factor for overall survival in all patients (hazard ratio [HR] 2.47; 95% confidence interval [CI], 1.01-2.85; P=.047). When stratified by disease stage, stage II intraoperative hypothermia was an independent prognostic factor for disease-free survival (HR 3.35; 95% CI, 1.27-8.83; P=.015) and overall survival (HR 4.24; 95% CI, 1.38-12.9; P=.011). This study suggests that intraoperative hypothermia could be a significant predictor for recurrence and survival in muscle-invasive bladder cancer treated with radical cystectomy.
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