Genetic variants at 10q23 are associated with risk of head and neck cancer in a Chinese population

Background: A recent genome-wide association study (GWAS) focused on esophageal squamous cell carcinoma (ESCC) has identified several susceptible regions (5q11, 21q22, 6p21 10q23, and 12q24) in Chinese population. We hypothesized that single nucleotide polymorphisms (SNPs) identified in these regions for ESCC were also associated with the risk of head and neck cancer (HNC) which share similar risk factors with ESCC. Methods: To test this hypothesis, we genotyped three SNPs (rs2274223, rs2014300 and rs10484761) in a case-control study with 503 HNC cases and 900 cancer-free controls in a Chinese population. Results: We found that rs2274223 was associated with a significantly increased risk of HNC in our population [GG vs. AA: adjusted odds ratio (OR) = 1.86, 95% confidence interval (CI) = 1.09-3.16; GG vs. (AG/AA): adjusted OR = 1.85, 95% CI = 1.09-3.12], and the effect appeared to be more prominent among drinkers (P = 0.024) and patients with oral cavity cancer (P = 0.019). In contrast, rs2014300 and rs10484761 variant were not observed any significantly association with risk of HNC. Conclusions: These results indicate that rs2274223 may be a marker SNP for HNC susceptibility in Chinese population. (C) 2012 Elsevier Ltd. All rights reserved.