Association analysis between MDR1 gene polymorphisms and risk of hepatocellular carcinoma in Chinese population

被引：7

作者：

Yang, Daokun ^{[1
]}

Zhou, Fujun ^{[2
]}

Wang, Xinwei ^{[1
]}

Gao, Haili ^{[1
]}

Li, Guangyan ^{[3
]}

Xue, Minghui ^{[1
]}

机构：

[1] Xinxiang Med Coll, Dept Infect Dis, Affiliated Hosp 1, Weihui 453100, Henan Province, Peoples R China

[2] Xinxiang Med Coll, Dept Pediat, Affiliated Hosp 1, Weihui 453100, Henan Province, Peoples R China

[3] Xinxiang Med Coll, Dept Gastroenterol, Affiliated Hosp 1, Weihui 453100, Henan Province, Peoples R China

来源：

BIOMARKERS | 2013年 / 18卷 / 03期

关键词：

Hepatocellular carcinoma; molecular marker; multidrug resistance 1 gene; risk factors; single nucleotide polymorphisms; susceptibility; P-GLYCOPROTEIN; MULTIDRUG-RESISTANCE; LIVER-TRANSPLANTATION; COMMERCIAL CATTLE; EXPRESSION LEVEL; CANCER; PATHOGENESIS; CARCINOGENESIS; EPIDEMIOLOGY; LEUKEMIA;

D O I：

10.3109/1354750X.2013.773079

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The objective of this study was to evaluate the association between MDR1 gene polymorphisms and hepatocellular carcinoma (HCC) risk. Genomic DNA of 1431 subjects was extracted from peripheral blood and genotyping was performed using the created restriction site-polymerase chain reaction (CRS-PCR). We found that the c.1465C>T single nucleotide polymorphisms (SNP) increased HCC risk in all genetic models (p<0.05) and the allele-T of c. 1465C>T may contribute to the risk of HCC. No significantly increased HCC risk was detected in c. 159G>T SNP. Our data indicated that the genetic variants of MDR1 gene may be a valuable molecular marker for HCC.

引用

页码：236 / 241

页数：6

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