Genetic regulation of thymocyte progenitor aging

被引：18
作者：
Berent-Maoz, Beata [1 ]
Montecino-Rodriguez, Encarnacion [1 ]
Dorshkind, Kenneth [1 ]
机构：
[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA
来源：
SEMINARS IN IMMUNOLOGY | 2012年 / 24卷 / 05期
关键词：
Thymus involution; Early T cell progenitors; p16(Ink4a); Rejuvenation; HEMATOPOIETIC STEM-CELLS; AGE-RELATED-CHANGES; GROWTH-FACTOR KGF; BONE-MARROW; SELF-RENEWAL; LYMPHOCYTE DEVELOPMENT; CELLULAR SENESCENCE; THYMIC FUNCTION; ADULT-MOUSE; FACTOR-I;
D O I：
10.1016/j.smim.2012.04.006
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The number of T cell progenitors is significantly reduced in the involuted thymus, and the growth and developmental potential of the few cells that are present is severely attenuated. This review provides an overview of how aging affects T cell precursors before and following entry into the thymus and discusses the age-related genetic changes that may occur in them. Finally, interventions that rejuvenate thymopoiesis in the elderly by targeting T cell progenitors are discussed. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：303 / 308
页数：6
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