Interleukin 22-producing CD4+ T cells in malignant pleural effusion

被引：79

作者：

Ye, Zhi-Jian ^{[1
]}

Zhou, Qiong ^{[1
]}

Yin, Wen ^{[1
]}

Yuan, Ming-Li ^{[1
]}

Yang, Wei-Bing ^{[1
]}

Xiang, Fei ^{[1
]}

Zhang, Jian-Chu ^{[1
]}

Xin, Jian-Bao ^{[1
]}

Xiong, Xian-Zhi ^{[1
]}

Shi, Huan-Zhong ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Resp & Crit Care Med, Key Lab Pulm Dis,Hlth Minist,Union Hosp, Wuhan 430022, Peoples R China

来源：

CANCER LETTERS | 2012年 / 326卷 / 01期

关键词：

Lung cancer; Malignant pleural effusion; Th22; cells; CYCLE ARREST; LUNG-CANCER; IL-22; DISTINCT; DISEASE; DIFFERENTIATION; LYMPHOCYTES; METASTASIS; INHIBITION; PATHWAYS;

D O I：

10.1016/j.canlet.2012.07.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Th22 cells have been reported to be involved in human cancers. However, differentiation and immune regulation of Th22 cells in malignant pleural effusion (MPE) remain unknown. We noted that Th22 cell numbers were increased in MPE, and that IL-22 substantially promoted the proliferation and migratory activity of A549 cells. Moreover, IL-22 could strongly facilitate intercellular adhesion of A549 cells to pleural mesothelial cell monolayers. Our data revealed that the increase in Th22 cells in MPE was due to pleural cytokines and chemokines, and that Th22 exerted an important immune regulation on cancer cells in human pleural malignant environment. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：23 / 32

页数：10

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