Two new lignans from the resin of Bursera microphylla A. gray and their cytotoxic activity

被引：8
作者：
Gigliarelli, Giulia [1 ]
Zadra, Claudia [1 ]
Cossignani, Lina [1 ]
Robles Zepeda, Ramon Enrique [2 ]
Alondra Rascon-Valenzuela, Luisa [2 ]
Arturo Velazquez-Contreras, Carlos [2 ]
Marcotullio, Maria Carla [1 ]
机构：
[1] Univ Perugia, Dept Pharmaceut Sci, Perugia, Italy
[2] Univ Sonora, Dept Ciencias Quim Biol, Div Ciencias Biol & Salud, Hermosillo, Sonora, Mexico
来源：
NATURAL PRODUCT RESEARCH | 2018年 / 32卷 / 22期
关键词：
Bursera microphylla; Burseraceae; lignans; dihydroclusin; 9-acetate; 7-O-podophyllotoxinyl butyrate; anti-proliferative activity; BIOLOGICAL-ACTIVITIES; CHEMICAL-COMPOSITION; ANTITUMOR AGENTS; PODOPHYLLOTOXIN; FAGAROIDES;
D O I：
10.1080/14786419.2017.1375922
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Two new lignans, namely 7-O-podophyllotoxinyl butyrate (1) and dihydroclusin 9-acetate (2), were isolated from the dichloromethane fraction of a methanol extract of Bursera microphylla (Burseraceae), along with eight known lignans (3-10). Their structures were determined by means of comprehensive spectroscopic analysis. Lignans 2-6 were tested for their anti-proliferative activity on the cancer cell lines LS180, A549 and HeLa, and on a non-cancer cell line, ARPE-19. Only compounds 4 and 5 showed an interesting activity on HeLa cells. [GRAPHICS]
引用
收藏
页码：2646 / 2651
页数：6
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