Two new lignans from the resin of Bursera microphylla A. gray and their cytotoxic activity

被引:8
作者
Gigliarelli, Giulia [1 ]
Zadra, Claudia [1 ]
Cossignani, Lina [1 ]
Robles Zepeda, Ramon Enrique [2 ]
Alondra Rascon-Valenzuela, Luisa [2 ]
Arturo Velazquez-Contreras, Carlos [2 ]
Marcotullio, Maria Carla [1 ]
机构
[1] Univ Perugia, Dept Pharmaceut Sci, Perugia, Italy
[2] Univ Sonora, Dept Ciencias Quim Biol, Div Ciencias Biol & Salud, Hermosillo, Sonora, Mexico
关键词
Bursera microphylla; Burseraceae; lignans; dihydroclusin; 9-acetate; 7-O-podophyllotoxinyl butyrate; anti-proliferative activity; BIOLOGICAL-ACTIVITIES; CHEMICAL-COMPOSITION; ANTITUMOR AGENTS; PODOPHYLLOTOXIN; FAGAROIDES;
D O I
10.1080/14786419.2017.1375922
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Two new lignans, namely 7-O-podophyllotoxinyl butyrate (1) and dihydroclusin 9-acetate (2), were isolated from the dichloromethane fraction of a methanol extract of Bursera microphylla (Burseraceae), along with eight known lignans (3-10). Their structures were determined by means of comprehensive spectroscopic analysis. Lignans 2-6 were tested for their anti-proliferative activity on the cancer cell lines LS180, A549 and HeLa, and on a non-cancer cell line, ARPE-19. Only compounds 4 and 5 showed an interesting activity on HeLa cells. [GRAPHICS]
引用
收藏
页码:2646 / 2651
页数:6
相关论文
共 50 条
[41]   Two new bioactive lignans from leaves and twigs of Cleistanthus concinnus Croizat [J].
Fan, Shi-rui ;
Guo, Jing-jing ;
Wang, Yi-ting ;
Yang, Bi-juan ;
Chen, Duo-zhi ;
Hao, Xiao-jiang .
NATURAL PRODUCT RESEARCH, 2020, 34 (23) :3328-3334
[42]   Two new lignans from the fresh roots of Zhongsheng No.1 Rehmannia glutinosa [J].
Li, Xiang-Da ;
Cao, Yan-Gang ;
Zhang, Yu-Han ;
Ren, Ying-Jie ;
Zeng, Meng-Nan ;
Liu, Yan-Ling ;
Chen, Xu ;
Ma, Xin-Yi ;
Zhao, Bing-Xian ;
Zheng, Xiao-Ke ;
Feng, Wei-Sheng .
PHYTOCHEMISTRY LETTERS, 2024, 61 :40-43
[43]   Two new cytotoxic ursane triterpenoids from the aerial parts of Salvia urmiensis Bunge [J].
Hashemi, Shima ;
Jassbi, Amir Reza ;
Erfani, Nasrollah ;
Kiani, Razieh ;
Seradj, Hassan .
FITOTERAPIA, 2021, 154
[44]   Schsphenines A and B, two new lignans from the fruit of Schisandra sphenanthera with cardioprotective Activities [J].
Yu, Jinyu ;
Yu, Wen ;
Wu, Xingan ;
Han, Jing .
NATURAL PRODUCT RESEARCH, 2024,
[45]   New lignans and acetophenone derivatives with α-glucosidase inhibitory activity from the leaves of Melicope patulinervia [J].
Vu, Van-Tuan ;
Manh-Tuyen Nguyen ;
Nguyen-Minh Khoi ;
Xu, Xiao-Juan ;
Kong, Ling-Yi ;
Luo, Jian-Guang .
FITOTERAPIA, 2021, 148
[46]   Synthesis, molecular structure, spectral analysis and cytotoxic activity of two new aroylhydrazones [J].
Singh, Ravindra Kumar ;
Singh, Ashok Kumar ;
Siddiqui, Sahabjada ;
Arshad, Mohammad ;
Jafri, Asif .
JOURNAL OF MOLECULAR STRUCTURE, 2017, 1135 :82-97
[47]   Two new compounds from endemic Centaurea paphlagonica (Bornm.) Wagenitz and their cytotoxic activities [J].
Tufekci, Ali Riza ;
Demirtas, Ibrahim ;
Aksit, Hueseyin ;
Arslan, Sevki ;
Kocabiyik, Kubra ;
Zeybek, Sibel ;
Ozen, Tevfik ;
Koksal, Ekrem .
CHEMICAL BIOLOGY & DRUG DESIGN, 2024, 103 (01)
[48]   Two new lignans from the aerial parts of Saururus chinensis with cytotoxicity toward nasopharyngeal carcinoma [J].
Cheng, Yanfang ;
Yin, Zhiyong ;
Jiang, Fuqiang ;
Xu, Jun ;
Chen, Hao ;
Gu, Qiong .
FITOTERAPIA, 2020, 141
[49]   Structural and spectroscopic characteristics of two new dibenzylbutane type lignans from Taxus baccata L. [J].
Erdemoglu, N ;
Sener, B ;
Ozcan, Y ;
Ide, S .
JOURNAL OF MOLECULAR STRUCTURE, 2003, 655 (03) :459-466
[50]   Isolation and structural elucidation of two novel lignans from the flowers of Gardenia jasminoides with potent α-glucosidase inhibitory activity [J].
Shao, Qingsen ;
Li, Huiyu ;
Li, Mingfeng ;
Yi, Wei ;
Zhou, Qiugui ;
Zheng, Lijuan ;
Wang, Meng ;
Hu, Hong-mei ;
Wen, Chao ;
Tang, Yun ;
Li, Wei .
PHYTOCHEMISTRY LETTERS, 2025, 67