Two new lignans from the resin of Bursera microphylla A. gray and their cytotoxic activity

被引：8

作者：

Gigliarelli, Giulia ^{[1
]}

Zadra, Claudia ^{[1
]}

Cossignani, Lina ^{[1
]}

Robles Zepeda, Ramon Enrique ^{[2
]}

Alondra Rascon-Valenzuela, Luisa ^{[2
]}

Arturo Velazquez-Contreras, Carlos ^{[2
]}

Marcotullio, Maria Carla ^{[1
]}

机构：

[1] Univ Perugia, Dept Pharmaceut Sci, Perugia, Italy

[2] Univ Sonora, Dept Ciencias Quim Biol, Div Ciencias Biol & Salud, Hermosillo, Sonora, Mexico

来源：

NATURAL PRODUCT RESEARCH | 2018年 / 32卷 / 22期

关键词：

Bursera microphylla; Burseraceae; lignans; dihydroclusin; 9-acetate; 7-O-podophyllotoxinyl butyrate; anti-proliferative activity; BIOLOGICAL-ACTIVITIES; CHEMICAL-COMPOSITION; ANTITUMOR AGENTS; PODOPHYLLOTOXIN; FAGAROIDES;

D O I：

10.1080/14786419.2017.1375922

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new lignans, namely 7-O-podophyllotoxinyl butyrate (1) and dihydroclusin 9-acetate (2), were isolated from the dichloromethane fraction of a methanol extract of Bursera microphylla (Burseraceae), along with eight known lignans (3-10). Their structures were determined by means of comprehensive spectroscopic analysis. Lignans 2-6 were tested for their anti-proliferative activity on the cancer cell lines LS180, A549 and HeLa, and on a non-cancer cell line, ARPE-19. Only compounds 4 and 5 showed an interesting activity on HeLa cells. [GRAPHICS]

引用

页码：2646 / 2651

页数：6

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