Expression of AQP5 and AQP8 in human colorectal carcinoma and their clinical significance

被引：57

作者：

Wang, Wei ^{[1
]}

Li, Qing ^{[2
]}

Yang, Tao ^{[1
]}

Bai, Guang ^{[1
]}

Li, Dongsheng ^{[1
]}

Li, Qiang ^{[1
]}

Sun, Hongzhi ^{[1
]}

机构：

[1] Liaoning Med Univ, Dept Gen Surg, Affiliated Hosp 1, Jinzhou 121001, Peoples R China

[2] Liaoning Med Univ, Affiliated Hosp 3, Dept Renal Med, Jinzhou 121001, Peoples R China

来源：

WORLD JOURNAL OF SURGICAL ONCOLOGY | 2012年 / 10卷

关键词：

AQP5; AQP8; Colorectal cancer; Immunohistochemistry; CANCER; OVEREXPRESSION; CARCINOGENESIS; SURVIVIN;

D O I：

10.1186/1477-7819-10-242

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: The aquaporins (AQPs) are a family of small membrane transport proteins whose overexpression has been implicated in tumorigenesis. However, the expression of AQP5 and AQP8 in colorectal cancer and the clinical significance remain unexplored. This study aimed to detect the expression of AQP5 and AQP8 in clinical samples of colorectal cancer and analyze the correlations of their expression with the clinicopathological features of colorectal cancer. Methods: Forty pairs of colorectal cancer tissue and paraneoplastic normal tissue were obtained at the time of surgery from patients with colorectal cancer. The expression of AQP5 and AQP8 was detected by immunohistochemical staining and reverse transcriptase polymerase chain reaction. Results: AQP5 was mainly expressed in colorectal carcinoma cells and barely expressed in paraneoplastic normal tissues. By contrast, AQP8 was mainly expressed in paraneoplastic normal tissues and barely expressed in colorectal carcinoma cells. AQP5 expression was not significantly associated with the sex or age of the patient with colorectal cancer (P>0.05), but was closely associated with the differentiation, tumor-nodes-metastasis stage and distant lymph node metastasis of colorectal carcinoma (P<0.05). Conclusions: AQP5 might be a novel prognostic biomarker for patients with colorectal cancer.

引用

页数：5

共 16 条

[11] NIRF is frequently upregulated in colorectal cancer and its oncogenicity can be suppressed by let-7a microRNA [J].

Wang, Feng ;

Zhang, Peng ;

Ma, Yanlei ;

Yang, Jianjun ;

Moyer, Mary Pat ;

Shi, Chenzhang ;

Peng, Jiayuan ;

Qin, Huanlong .

CANCER LETTERS, 2012, 314 (02) :223-231

[12] Overexpression of AQP5, a putative oncogene, promotes cell growth and transformation [J].

Woo, Janghee ;

Lee, Juna ;

Chae, Young Kwang ;

Kim, Myoung Sook ;

Baek, Jin Hyen ;

Park, Jong Chul ;

Park, Min Joo ;

Smith, Ian M. ;

Trink, Barry ;

Ratovitski, Edward ;

Lee, Taekyul ;

Park, Bumsoo ;

Jang, Se Jin ;

Soria, Jean C. ;

Califano, Joseph A. ;

Sidransky, David ;

Moon, Chulso .

CANCER LETTERS, 2008, 264 (01) :54-62

[13] Significant Elevation of Survivin and Livin Expression in Human Colorectal Cancer: Inverse Correlation between Expression and Overall Survival [J].

Xi, Ren Chong ;

Biao, Wang Shou ;

Gang, Zhang Zhi .

ONKOLOGIE, 2011, 34 (8-9) :428-432

[14] Inhibitory effect of Epigallocatechin gallate on ovarian cancer cell proliferation associated with aquaporin 5 expression [J].

Yan, Chunxiao ;

Yang, Jianhua ;

Shen, Lan ;

Chen, Xuejun .

ARCHIVES OF GYNECOLOGY AND OBSTETRICS, 2012, 285 (02) :459-467

[15]

Yang JH, 2011, HISTOL HISTOPATHOL, V26, P1197, DOI 10.14670/HH-26.1197

[16] Overexpression of AQP5 in cervical cancer: correlation with clinicopathological features and prognosis [J].

Zhang, Ting ;

Zhao, Chun ;

Chen, Daozhen ;

Zhou, Zuomin .

MEDICAL ONCOLOGY, 2012, 29 (03) :1998-2004

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