Analysis of anti-PDE3 activity of 2-morpholinochromone derivatives reveals multiple mechanisms of anti-platelet activity

被引：4
作者：
Abbott, BM
Thompson, PE [1 ]
机构：
[1] Monash Univ, Victorian Coll Pharm, Dept Med Chem, Parkville, Vic 3052, Australia
[2] Monash Univ, Dept Med, Box Hill Hosp, Box Hill, Vic 3128, Australia
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 04期
基金：
澳大利亚研究理事会;
关键词：
phosphodiesterase; inhibitor; PDE3; platelet; 2-morpholinochromone;
D O I：
10.1016/j.bmcl.2005.10.092
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of synthetic 2-morpholinochromones have been evaluated as inhibitors of platelet phosphodiesterase, PDE3A. While previous assertions about the anti-PDE3 activity of this class have been confirmed, in some cases the reported anti-platelet activities clearly derive from a non-PDE3 regulated mechanism. The potential utility of 2-morpholinochromones either as PDE3 inhibitors and/or anti-thrombotic agents thus remains only poorly examined. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：969 / 973
页数：5
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